NDLI: Corneal complications in streptozocin-induced type I diabetic rats.

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Corneal complications in streptozocin-induced type I diabetic rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Cynthia Huang, Jenny Yu, Fu-Shin X. Yin, Jia Gao, Nan Wang, Feng
Description	Country affiliation: United States Author Affiliation: Yin J ( Kresge Eye Institute, Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.)
Abstract	PURPOSE. This study seeks to characterize corneal functions and complications in a streptozocin (STZ)-induced rat model of type I diabetes mellitus (DM) and to understand the pathogenesis of diabetic keratopathy. METHODS. DM was induced via STZ injection in Sprague-Dawley rats. Body weight, length, and corneal size were measured and compared with the age-matched normal controls. Corneal morphology and histology were evaluated with slit lamp, digital confocal microscopy and hematoxylin and eosin staining. Tear secretion was measured with cotton threads, and corneal sensitivity was determined with an esthesiometer. Protein expression and distribution were assessed with Western blotting and immunohistochemistry. Wound healing was determined using an in vivo corneal epithelial debridement model. RESULTS. Compared with the normal control rats, STZ rats had reduced body weight, and body length, but minimally affected corneal size. No significant changes in ocular surface regularity, corneal thickness, and morphology were noted in diabetic corneas. STZ rats showed stronger Rose Bengal staining, decreased tear secretion, slightly attenuated sensitivity, less innervation, delayed epithelial wound healing, and impaired epidermal growth factor receptor signaling in their corneas. While the expression of adherens junction protein ß-catenin, and tight junction proteins occludin and ZO-1 was unchanged, the formation of these junctions after wound closure was delayed. CONCLUSIONS. Pathogenesis of diabetic keratopathy involves multiple tissues and/or cell types and several events including reduced tear secretion, impaired innervation, weakened cell junction, and altered wound responses. These insights may prove useful for the clinical translation of evolving strategies for the management and treatment of diabetic corneal complications.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.11-7709
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Corneal Diseases Etiology Diabetes Mellitus, Experimental Complications Diabetes Mellitus, Type 1 Animals Blotting, Western Body Constitution Cornea Metabolism Physiopathology Immunohistochemistry Lacrimal Apparatus Diseases Membrane Proteins Microscopy, Confocal Occludin Ophthalmic Nerve Phosphoproteins Rats, Sprague-dawley Receptor, Epidermal Growth Factor Signal Transduction Secretion Trigeminal Nerve Diseases Wound Healing Zonula Occludens-1 Protein Beta Catenin Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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