NDLI: Ceramide-1-phosphate, a new mediator of development and survival in retina photoreceptors.

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Ceramide-1-phosphate, a new mediator of development and survival in retina photoreceptors.

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Ceramide-1-phosphate, a new mediator of development and survival in retina photoreceptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rotstein, Nora P. Miranda, Gisela E. Politi, Luis E. Abrahan, Carolina E. Agnolazza, Daniela L.
Description	Country affiliation: Argentina Author Affiliation: Miranda GE ( Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Universidad Nacional del Sur (UNS), Buenos Aires, Argentina.)
Abstract	PURPOSE. Simple sphingolipids control crucial cellular processes in several cell types. Previous work demonstrated that sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate, are key mediators in the regulation of survival, differentiation, and proliferation of retina photoreceptors. Ceramide-1-phosphate (C1P) regulates growth and survival in several cell types; however, little is known concerning its functions in the retina. Whether C1P also participates in controlling photoreceptor development was also explored. METHODS. Rat retina neuronal cultures were supplemented with 1 to 10 µM C1P. Proliferation was determined by evaluating 5-bromo-2-deoxyuridine (BrdU) uptake and the number of mitotic figures and differentiation by evaluating opsin and peripherin expression by immunocytochemistry and Western blot. Apoptosis was inhibited with the pan caspase inhibitor ZVADFMK and evaluated by TUNEL assay, propidium iodide/annexin V, and DAPI labeling. Preservation of mitochondrial membrane potential was evaluated. RESULTS. C1P enhanced BrdU uptake and increased mitosis in retinal progenitors. C1P addition advanced photoreceptor differentiation, enhancing opsin and peripherin expression and stimulating development of the apical processes in which these proteins were concentrated. In the absence of these trophic factors, photoreceptors degenerated after 4 days in vitro, and at day 6, almost 50% of photoreceptors were apoptotic. C1P decreased photoreceptor apoptosis, reducing this percentage by half. Inhibiting caspase activity reduced photoreceptor apoptosis in the controls, but did not increase opsin expression, implying that C1P has separate effects on differentiation and survival. CONCLUSIONS. These results suggest for the first time that C1P is a novel mediator that has multiple functions in photoreceptors, initially regulating their proliferation and then promoting their survival and differentiation.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Drug Effects Cell Differentiation Ceramides Pharmacology Photoreceptor Cells, Vertebrate Cytology Stem Cells Animals Blotting, Western Cell Proliferation Cell Survival Cells, Cultured Fluorescent Antibody Technique, Indirect In Situ Nick-end Labeling Intermediate Filament Proteins Metabolism Membrane Glycoproteins Membrane Potential, Mitochondrial Physiology Microscopy, Fluorescence Nerve Tissue Proteins Opsins Peripherins Rats, Wistar Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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