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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Blann, Andrew D. Heitmar, Rebekka Lip, Gregory Y. H. Cubbidge, Robert P. Gherghel, Doina |
| Description | Country affiliation: United kingdom Author Affiliation: Heitmar R ( Aston University, School of Life and Health Sciences, Birmingham, United Kingdom. r.heitmar1@aston.ac.uk) |
| Abstract | PURPOSE: Cardiac function, such as heart rate variability, is abnormal in coronary artery disease, but its relation with the function of ocular and nail-fold blood vessels is unknown. The hypothesis was that there is abnormal retinal and peripheral microvascular endothelial function compared with large blood vessel and cardiac function. Twenty-four patients with coronary artery disease (CAD) and 30 healthy, age- and sex-matched control subjects were enrolled in the study. METHODS: Peripheral microcirculatory function was measured with continuous retinal vessel diameter assessment and nail-fold capillaroscopy. Systemic vascular function was evaluated by 24-hour blood pressure, arterial stiffness, low (LF)- and high (HF)-frequency heart rate variability, ECG monitoring, and the plasma markers von Willebrand factor (vWf) and soluble E selectin. RESULTS: Peripheral nail-fold capillary (P = 0.009) and retinal vessel (average baseline corrected flicker response [BFR]; P = 0.034) responses and reaction time in response to flicker (P = 0.016) were significantly different in patients compared with controls. Furthermore, patients demonstrated higher arterial stiffness (P = 0.005), LF and HF heart rate variability (P = 0.004, P = 0.006), and vWf level (P = 0.044), but there was no difference in soluble E selectin level (P = 0.278). In the CAD patients, LF and HF heart rate variability both correlated with average BFR (r = 0.58, P = 0.004; r = -0.6, P = 0.003, respectively). There was no such relationship in the healthy controls. CONCLUSIONS: Microcirculatory abnormalities of the retina and nail-fold vessels are present in CAD. The two indices of heart rate variability correlated with an index of ocular vessel responses. The latter may be a surrogate marker of abnormal heart rate variability in CAD. |
| ISSN | 01460404 |
| e-ISSN | 15525783 |
| Journal | Investigative Opthalmology & Visual Science |
| Issue Number | 9 |
| Volume Number | 52 |
| Language | English |
| Publisher | Association for Research in Vision and Ophthalmology |
| Publisher Date | 2011-08-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Ciliary Arteries Physiopathology Coronary Artery Disease Fingers Blood Supply Ophthalmic Artery Retinal Artery Blood Flow Velocity Blood Pressure Physiology Case-control Studies E-selectin Blood Electrocardiography Enzyme-linked Immunosorbent Assay Heart Rate Intraocular Pressure Supine Position Von Willebrand Factor Metabolism Discipline Ophthalmology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
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