NDLI: Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery.

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Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery.

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Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, Erin M. Shen, Tueng T. Shirakawa, Rika Noble, Misty L. Bryers, James D. Warsen, Adelaide Ratner, Buddy D. Garty, Shai
Description	Country affiliation: United States Author Affiliation: Garty S ( University of Washington Eye Institute, Seattle, Washington, USA.)
Abstract	PURPOSE: To develop a simple, novel polymeric drug-delivery device for prevention of postoperative bacterial infection after cataract surgery in the developing world. METHODS: A poly(2-hydroxyethyl-methacrylate) (pHEMA) hydrogel was developed to achieve sustained release characteristics of antibiotics. The in vitro antibiotic release kinetics and efficacy of antibiotic function were tested using a silicone biofilm model. In vivo feasibility was investigated using a rabbit model. The control group of rabbits underwent standard cataract surgery with intraocular lens (IOL) implant and postoperative topical antibiotic and steroid. The experimental group received the polymeric device inserted with standard three-piece IOL at the time of surgery and received only topical steroids postoperatively. In vivo intraocular antibiotic levels and outcomes after cataract surgery were evaluated. RESULTS: The in vitro studies demonstrate the antibiotic release kinetics can be controlled by optimization of the surface coating. The in vivo results showed sustained sufficient antibiotic concentration (above minimum inhibitory concentration for most common bacteria related to endophthalmitis) for >4 weeks. There was minimum toxicity observed in vivo. The device was effective in treating induced intraocular infection after cataract surgery. CONCLUSIONS: The initial findings of the polymeric drug-delivery device demonstrate the feasibility delivering sufficient antibiotic in the anterior chamber for the immediate postoperative period in a rabbit model. The device is simple to produce and may help alleviate the potential postsurgical infections in the developing nations.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-03
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anti-bacterial Agents Administration & Dosage Cataract Extraction Coated Materials, Biocompatible Drug Carriers Lenses, Intraocular Norfloxacin Animals Colony Count, Microbial Delayed-action Preparations Endophthalmitis Prevention & Control Eye Infections, Bacterial Microscopy, Electron, Scanning Models, Animal Polyhydroxyethyl Methacrylate Chemistry Rabbits Staphylococcus Epidermidis Drug Effects Surgical Wound Infection Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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