NDLI: Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea.

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Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea.

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Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stachs, Oliver Eule, Johanna C. Baltrusch, Simone Behrendt, Ann-Kathrin Reichard, Maria Leppin, Katja Guthoff, Rudolf F. Vollmar, Brigitte
Description	Country affiliation: Germany Author Affiliation: Leppin K ( Institute for Experimental Surgery, University of Rostock, Rostock, Germany.); Behrendt AK ( Institute for Experimental Surgery, University of Rostock, Rostock, Germany.); Reichard M ( Department of Ophthalmology, University of Rostock, Rostock, Germany.); Stachs O ( Department of Ophthalmology, University of Rostock, Rostock, Germany.); Guthoff RF ( Department of Ophthalmology, University of Rostock, Rostock, Germany.); Baltrusch S ( Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany.); Eule JC ( Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.); Vollmar B ( Institute for Experimental Surgery, University of Rostock, Rostock, Germany.)
Abstract	PURPOSE: To evaluate whether nerve fibers of the subbasal nerve plexus (SNP) and dendritic cells (DCs) are in association with each other leading to neuropathy in the diabetic cornea. METHODS: BALB/c mice were injected with streptozotocin (STZ) for 5 days for induction of diabetes mellitus (DM) or with vehicle solution (control). B6.VLep(ob/ob) (ob/ob) mice served as an obese and glucose-intolerant DM type 2 (DM II) model and lean B6.VLep(ob/+) (ob/+) mice as respective controls. Using in vivo corneal confocal microscopy (CCM), nerve fibers and DCs were quantified over a period of 9 weeks and additionally analyzed by in vitro immunofluorescence whole-mount staining. RESULTS: In STZ-diabetic mice, CCM revealed an increase of DC density (DCD) in contrast to controls, whereas nerve fiber density (NFD) was decreased with duration of DM. In ob/ob mice, DCD was 3-fold higher than in both ob/+ mice and STZ-diabetic mice. Whole-mount staining displayed CD11c(+) and major histocompatibility complex (MHC) class II(+) mature DCs in colocalization with class III ß-tubulin(+) nerve fibers in the cornea. CONCLUSIONS: Hyperglycemia leads to corneal DC infiltration, and obesity aggravates this immune response. The direct contact between DCs and the SNP can be assumed to be a trigger of nerve fiber damage and thus a contributing factor to polyneuropathy in diabetic corneas.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	6
Volume Number	55
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2014-04-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cornea Corneal Diseases Etiology Dendritic Cells Pathology Diabetes Mellitus, Experimental Nerve Fibers Ophthalmic Nerve Animals Cell Count Complications Mice Mice, Inbred Balb C Microscopy, Confocal Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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