NDLI: Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics.

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Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics.

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Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cense, Barry Bruestle, Jeremy Kocaoglu, Omer P. Wang, Qiang Jonnal, Ravi S. Gao, Weihua Miller, Donald T.
Description	Country affiliation: United States Author Affiliation: Wang Q ( School of Optometry, Indiana University, Bloomington, Indiana 47405, USA. wangqi@indiana.edu)
Abstract	PURPOSE: Ultrahigh-resolution optical coherence tomography (UHR-OCT) with adaptive optics (AO) provides micrometer-scale 3D resolution that is attractive for imaging the retinal microvasculature. Such imaging may be useful for early detection of pathologic changes as in diabetic retinopathy. Here the authors investigate this potential for detecting individual capillaries in healthy subjects. METHODS: UHR-AO-OCT volumes centered on the fovea were acquired from seven subjects (age range, 25-61 years) with three preselected with no foveal avascular zone (FAZ). Images were compared with entoptic diagrams using the capillaries at the rim of the FAZ. Methods of comparison were testing for the presence of a FAZ, noting distinct features in the capillary pattern, and measuring the size of the FAZ. Additional analysis included measurements of capillary diameter and depth range with retinal eccentricity. RESULTS: UHR-AO-OCT results are consistent with entoptic observations for all three methods of comparison. FAZ diameters measured by UHR-AO-OCT and entoptic imaging are strongly correlated (R(2) = 0.86). Average capillary diameter near the FAZ rim is 5.1 (4.6) ± 1.4 µm, with the value in parentheses accounting for axial image blur. This is consistent with histology (average, ~4.7 µm). Depth range of the capillaries increases monotonically with eccentricity (0°-1.25°) and is larger and more variable for subjects without FAZ. CONCLUSIONS: UHR-AO-OCT permits observation of many of the capillaries proximal to the FAZ, including those of average size based on published histology. This supports the view that the vast majority of capillaries in the retina are likely detectable with UHR-AO-OCT.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.10-6424
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Capillaries Anatomy & Histology Retinal Vessels Tomography, Optical Coherence Axial Length, Eye Fovea Centralis Blood Supply Vision, Entoptic Physiology Visual Acuity Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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