NDLI: Quantitative evaluation of retinal response to laser photocoagulation using dual-wavelength fundus autofluorescence imaging in a small animal model.

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Quantitative evaluation of retinal response to laser photocoagulation using dual-wavelength fundus autofluorescence imaging in a small animal model.

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Quantitative evaluation of retinal response to laser photocoagulation using dual-wavelength fundus autofluorescence imaging in a small animal model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boretsky, Adam Motamedi, Massoud Van Kuijk, Frederik Bell, Brent
Description	Country affiliation: United States Author Affiliation: Boretsky A ( Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555-1106, USA.)
Abstract	PURPOSE: To demonstrate the usefulness of dual-wavelength fundus autofluorescence (FAF) imaging for noninvasive, quantitative monitoring of dynamic changes associated with healing of retinal photocoagulation lesions in a small animal model. METHODS: Brown Norway rats, exhibiting substantial age-dependent lipofuscin autofluorescence, were used to characterize the kinetics of FAF recovery after retinal photocoagulation. An argon laser with a beam diameter of 100 µm, exposure duration of 0.1 seconds, and a range of laser powers (8-22 mW) were used to create subthreshold, threshold, and suprathreshold lesions. A modified retinal angiograph was used to obtain dual-wavelength FAF images at 488 and 514 nm to quantify and monitor changes in retinal fluorescence up to 6 months. RESULTS: Compared to white light funduscopy, the FAF images exhibited heightened definition and clarity of lesion boundaries immediately after laser exposure. No significant reduction in FAF was measured at or below laser powers of 8 mW. Furthermore, a linear, dose-dependent decrease in FAF (R(2) = 0.9605) was observed immediately after laser exposures of 13 to 22 mW. Complete recovery of baseline FAF was observed for 13.5 and 16 mW exposures at 3 weeks and 4 months, respectively. However, retinal damage was still evident at 6 months after suprathreshold exposure induced using 22 mW laser power. CONCLUSIONS: The accumulation of lipofuscin in the aged Brown Norway rat makes it a suitable small animal model for the characterization of laser-induced injury in the retina based on FAF. Dual-wavelength FAF measurements provide a sensitive, quantitative, noninvasive means of monitoring recovery of laser-induced retinal injury.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fluorescein Angiography Laser Coagulation Adverse Effects Retina Injuries Retinal Pigment Epithelium Metabolism Wound Healing Physiology Animals Lasers, Gas Lipofuscin Models, Animal Ophthalmoscopy Rats, Inbred Bn Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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