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Missing optomotor head-turning reflex in the DBA/2J mouse.

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Missing optomotor head-turning reflex in the DBA/2J mouse.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Krizaj, David Howell, Gareth Chen, Hui John, Simon W. M. Huang, Wei Koehler, Christopher L. Tian, Ning Barabas, Peter Rentería, René C.
Description	Country affiliation: United States Author Affiliation: Barabas P ( Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. sirmook12@gmail.com)
Abstract	PURPOSE: The optomotor reflex of DBA/2J (D2), DBA/2J-Gpnmb+ (D2-Gpnmb+), and C57BL/6J (B6) mouse strains was assayed, and the retinal ganglion cell (RGC) firing patterns, direction selectivity, vestibulomotor function and central vision was compared between the D2 and B6 mouse lines. METHODS: Intraocular pressure (IOP) measurements, real-time PCR, and immunohistochemical analysis were used to assess the time course of glaucomatous changes in D2 retinas. Behavioral analyses of optomotor head-turning reflex, visible platform Morris water maze and Rotarod measurements were conducted to test vision and vestibulomotor function. Electroretinogram (ERG) measurements were used to assay outer retinal function. The multielectrode array (MEA) technique was used to characterize RGC spiking and direction selectivity in D2 and B6 retinas. RESULTS: Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age. D2 mice showed no response to visual stimulation that evoked robust optomotor responses in B6 mice at any age after eye opening. Spatial frequency threshold was also not measurable in the D2-Gpnmb+ strain control. ERG a- and b-waves, central vision, vestibulomotor function, the spiking properties of ON, OFF, ON-OFF, and direction-selective RGCs were normal in young D2 mice. CONCLUSIONS: The D2 strain is characterized by a lack of optomotor reflex before IOP elevation and RGC degeneration are observed. This behavioral deficit is D2 strain-specific, but is independent of retinal function and glaucoma. Caution is advised when using the optomotor reflex to follow glaucoma progression in D2 mice.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.10-7147
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-08-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Physiopathology Head Movements Physiology Retinal Ganglion Cells Animals Behavior, Animal Disease Models, Animal Electroretinography Gene Expression Genetics Metabolism Immunohistochemistry Intraocular Pressure Mice Mice, Inbred C57bl Mice, Inbred Dba Photic Stimulation Polymerase Chain Reaction Transcription Factor Brn-3a Biosynthesis Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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