NDLI: Tracking dendritic shrinkage of retinal ganglion cells after acute elevation of intraocular pressure.

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Tracking dendritic shrinkage of retinal ganglion cells after acute elevation of intraocular pressure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yung, Wing-ho Leung, Christopher Kai-shun Lindsey, James D. Weinreb, Robert N. Ye, Cong Yu, Marco Liu, Lan Lam, Dennis Shun Chiu Liu, Shu Li, Zhi-wai Cui, Qiaoling Pang, Chi-Pui
Description	Country affiliation: China Author Affiliation: Li ZW ( Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China.)
Abstract	PURPOSE: To investigate dendritic changes of retinal ganglion cells (RGCs) and the rate of dendritic shrinkage after retinal ischemia induced by acute elevation of intraocular pressure (IOP). METHODS: After elevating the IOP to 110 mm Hg for 30, 60, 90, and 120 minutes, a confocal scanning laser ophthalmoscope (CSLO) was used to serially image the retinas of the Thy-1 YFP transgenic mice in vivo for 1 to 3 months. Dendritic and axonal arborizations of 52 RGCs were visualized and followed longitudinally. Dendritic field, dendritic branching complexity (modified Sholl analysis), axonal diameter, and cell body area were measured. A total of 426 longitudinal measurements of dendritic field and dendritic complexity were analyzed for estimation of rate of change with linear mixed modeling. RESULTS: There were no morphologic changes of RGCs after 30 (n = 12) or 60 (n = 12) minutes of ischemia. After 90 minutes of ischemia (n = 19), 78.9% of RGCs showed progressive loss of dendrites, axon, and cell body, 5.3% had only mild reduction of branching complexity and shrinkage of dendritic field whereas 15.8% showed no morphologic changes. All RGCs lost dendritic and axonal arborizations after 120 minutes of ischemia (n = 9). The rates of reduction of dendritic field were 11.7% per day (95% confidence interval, 5.0%-18.4% per day) after 90 minutes, and 15.1% per day (10.3%-19.9% per day) after 120 minutes of ischemia. CONCLUSIONS: RGCs demonstrated dendritic shrinkage after 90 to 120 minutes, but not after 30 to 60 minutes of ischemia. In vivo imaging of dendritic changes could provide a sensitive approach to measure the rate of dendritic shrinkage after acute IOP elevation.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-14
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dendrites Pathology Intraocular Pressure Reperfusion Injury Retinal Degeneration Retinal Ganglion Cells Animals Antigens, Thy-1 Metabolism Axons Disease Models, Animal Fluorescent Antibody Technique, Indirect Mice Mice, Inbred C57bl Mice, Transgenic Microscopy, Confocal Ocular Hypertension Complications Etiology Time Factors Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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