NDLI: Transforming growth factor-ß inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.

Please wait, while we are loading the content...

Comparison of standard automated perimetry, frequency-doubling technology perimetry, and short-wavelength automated perimetry for detection of glaucoma.

The pattern of learned visual improvements in adult amblyopia.

Rod Sensitivity, Cone Sensitivity, and Photoreceptor Layer Thickness in Retinal Degenerative Diseases

Transforming growth factor-ß inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.

A comprehensive evaluation of the precision (repeatability and reproducibility) of the Oculus Pentacam HR.

Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease.

174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy.

The antiangiogenic effects of integrin alpha5beta1 inhibitor (ATN-161) in vitro and in vivo.

Lamina-specific anatomic magnetic resonance imaging of the human retina.

Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy.

The effects of Mozart's music on the performance of glaucoma patients on automated perimetry.

Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension.

The High-Mobility Group Box-1 Nuclear Factor Mediates Retinal Injury after Ischemia Reperfusion

Hydroxyapatite for keratoprosthesis biointegration.

Analysis of the composition of lipid in human meibum from normal infants, children, adolescents, adults, and adults with meibomian gland dysfunction using ¹H-NMR spectroscopy.

Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.

Inducers of cross-linked actin networks in trabecular meshwork cells.

Tear production and ocular surface changes in experimental dry eye after elimination of desiccating stress.

Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

Normative database for corneal backscatter analysis by in vivo confocal microscopy.

Effects of brief daily periods of unrestricted vision during early monocular form deprivation on development of visual area 2.

Tumor-associated lymphangiogenesis in the development of conjunctival melanoma.

Efficacy of a computerized optokinetic nystagmus test in prediction of visual acuity of better than 20/200.

Retinal gene expression and visually evoked behavior in diabetic long evans rats.

Differential association of serum lipids with diabetic retinopathy and diabetic macular edema.

The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties.

Differential expression of claudins in retinas during normal development and the angiogenesis of oxygen-induced retinopathy.

Simple estimation of clinically relevant lesion volumes using spectral domain-optical coherence tomography in neovascular age-related macular degeneration.

Racial differences in the prevalence of diabetes but not diabetic retinopathy in a multi-ethnic Asian population.

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).

Fluvastatin downregulates VEGF-A expression in TNF- -induced retinal vessel tortuosity.

Mpdz null allele in an avian model of retinal degeneration and mutations in human leber congenital amaurosis and retinitis pigmentosa.

Automated analysis of optic nerve images for detection and staging of papilledema.

Atypical retardation patterns in scanning laser polarimetry are associated with low peripapillary choroidal thickness.

Effect of infliximab on gene expression profiling in Behcet's disease.

The influence of alloxan-induced diabetes on Müller cell contraction-promoting activities in vitreous.

Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model.

In vivo cross-sectional observation and thickness measurement of bulbar conjunctiva using optical coherence tomography.

The KORA Eye Study: a population-based study on eye diseases in Southern Germany (KORA F4).

Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe).

Literacy is an independent risk factor for vision impairment and poor visual functioning.

Numerical modeling of paintball impact ocular trauma: identification of progressive injury mechanisms.

PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.

Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration.

Enhancement of ON-bipolar cell responses of cone electroretinograms in rabbits with the Pro347Leu rhodopsin mutation.

Molecular chaperone function for myocilin.

Endothelin-1-induced proliferation is reduced and Ca²â º signaling is enhanced in endothelin B-deficient optic nerve head astrocytes.

Cross-sectional sample of peripheral refraction in four meridians in myopes and emmetropes.

Target search and identification performance in low vision patients.

Repair of strabismus and binocular fusion in children with cerebral palsy: gross motor function classification scale.

The small GTPase Rap1 is a novel regulator of RPE cell barrier function.

Elevated systemic neutrophil count in diabetic retinopathy and diabetes: a hospital-based cross-sectional study of 30,793 Korean subjects.

Reduction of apoptosis in ischemic retinas of two mouse models using hyperbaric oxygen treatment.

Photochemical properties of UV Filter molecules of the human eye.

Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration.

Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles.

Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

Assessment of cone survival in response to CNTF, GDNF, and VEGF165b in a novel ex vivo model of end-stage retinitis pigmentosa.

Changes in vision- and health-related quality of life in patients with diabetic macular edema treated with pegaptanib sodium or sham.

Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar rats.

Associations of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genotypes with subtypes of polypoidal choroidal vasculopathy.

Muller glia, vision-guided ocular growth, retinal stem cells, and a little serendipity: the Cogan lecture.

Why HLA-B27? My thirty-year quest: the Friedenwald lecture.

Reflections on 'hot' blind spots: lessons from research on aging macula disorder and glaucoma: the Weisenfeld lecture.

Current gene discovery strategies for ocular conditions.

Year: 2011 Volume: 52 Issue: 9

Year: 2011 Volume: 52 Issue: 8

Year: 2011 Volume: 52 Issue: 7

Year: 2011 Volume: 52 Issue: 6

Year: 2011 Volume: 52 Issue: 5

Year: 2011 Volume: 52 Issue: 4

Year: 2011 Volume: 52 Issue: 3

Year: 2011 Volume: 52 Issue: 2

Year: 2011 Volume: 52 Issue: 1

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Transforming growth factor-ß inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	García-Gómez, Pío J. Dotor, Javier García-Layana, Alfredo Zarranz-Ventura, Javier Recalde, Sergio Fernández-Robredo, Patricia Salinas-Alamán, Angel Borrás-Cuesta, Francisco
Description	Author Affiliation: Recalde S ( Experimental Ophthalmology Laboratory.)
Abstract	PURPOSE: To assess the effect of transforming growth factor (TGF)-ß inhibitor peptides (P17 and P144) on the development of laser-induced choroidal neovascularization (LI-CNV) in a rat model. METHODS: Sixty-one Long-Evans rats underwent diode LI-CNV model. Forty-eight hours later, treatment was administered. The intravenous control group (IV-control) and intravenous P17 group (IV-17) received five doses (0.2 mg every 72 hours) of vehicle and P17, respectively. Four groups received intravitreal injections of P17 low-dose (LD-17; 1 mg/mL) and high-dose (HD-17; 20 mg/mL) and P144 low-dose (LD-144; 1 mg/mL) and high-dose (HD-144; 3 mg/mL), and fellow eyes received vehicle. CNV evolution was assessed weekly by fluorescein angiography (FA). After death, VEGF, TGF-ß and PDGF protein levels were measured by ELISA in RPE and retina homogenates. Data were analyzed with commercially available statistical analysis software. RESULTS: The mean CNV area, measured in pixels, was significantly lower at the second and fourth weeks in IV-17 (P < 0.05) and from the second week in HD-17 (P < 0.05), whereas LD-144 and HD-144 showed significant differences at every time point (P < 0.05). LD-17 showed significantly lower protein levels of TGF-ß in retina and PDGF in RPE (P < 0.05), whereas HD-17 showed lower levels of VEGF (RPE and retina; P < 0.05), TGF-ß (RPE and retina; P < 0.05), and PDGF (RPE; P < 0.05). HD-144 showed lower VEGF levels in the retina (P < 0.05). CONCLUSIONS: TGF-ß inhibition with these peptides represents a promising new therapeutic line for CNV targeting a different pathway than current therapies. More studies are needed to assess this effect on early CNV, alone or in combination with anti-VEGF.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-09
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Choroidal Neovascularization Drug Therapy Disease Models, Animal Peptide Fragments Pharmacology Peptides Transforming Growth Factor Beta Antagonists & Inhibitors Animals Metabolism Pathology Enzyme-linked Immunosorbent Assay Fluorescein Angiography Injections, Intravenous Intravitreal Injections Laser Coagulation Lasers, Semiconductor Platelet-derived Growth Factor Rats, Long-evans Receptors, Transforming Growth Factor Beta Vascular Endothelial Growth Factor A Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Safe dose of intravitreal imatinib and its effect on laser-induced choroidal neovascularization: a rat-model experiment

Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment

Transforming Growth Factor-Beta Inhibition Reduces Progression of Early Choroidal Neovascularization Lesions in Rats: P17 and P144 Peptides

Intravitreal Triamcinolone Acetonide Inhibits Choroidal Neovascularization in a Laser-Treated Rat Model

Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy.

Reduction of laser-induced choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes.

Intravitreal bevacizumab for iatrogenic choroidal neovascularization due to laser photocoagulation in central serous chorioretinopathy.

The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization.

Intravitreal Bevacizumab Injection for the Treatment of Choroidal Neovascularization Secondary to Candida Chorioretinitis

Transforming growth factor-ß inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.

Similar Documents

Safe dose of intravitreal imatinib and its effect on laser-induced choroidal neovascularization: a rat-model experiment

Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment

Transforming Growth Factor-Beta Inhibition Reduces Progression of Early Choroidal Neovascularization Lesions in Rats: P17 and P144 Peptides

Intravitreal Triamcinolone Acetonide Inhibits Choroidal Neovascularization in a Laser-Treated Rat Model

Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy.

Reduction of laser-induced choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes.

Intravitreal bevacizumab for iatrogenic choroidal neovascularization due to laser photocoagulation in central serous chorioretinopathy.

The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization.

Intravitreal Bevacizumab Injection for the Treatment of Choroidal Neovascularization Secondary to Candida Chorioretinitis

Transforming growth factor-ß inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.