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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Meng Guo, Li Salt, Thomas E. Cordeiro, Maria Francesca |
| Description | Country affiliation: United kingdom Author Affiliation: Liu M ( Glaucoma and Retinal Neurodegeneration Research Group, UCL Institute of Ophthalmology , London , United Kingdom .) |
| Abstract | PURPOSE: Increasing evidence shows that structural changes in dendrites play an important role in neuronal degenerative processes. The aims of this study were to characterize and delineate morphological changes of dendrites in retinal ganglion cells (RGCs) and their central target neurons in the superior colliculus (SC) and lateral geniculate nucleus (LGN) in experimental rat glaucoma. METHODS: Chronic ocular hypertension (OHT) was surgically induced in rats and animals were sacrificed at 1, 4, 8, 16 and 32 weeks following IOP elevation. Animals without IOP elevation served as normal control. Dendritic morphology of neurons was visualized by ex vivo DiI labelling using confocal microscopy and dendritic length and number was quantified using Image J. RESULTS: We found significant dendritic shrinkage (p < 0.001) and loss (p < 0.001) in RGCs and neurons in the SC and LGN in OHT animals compared to age-matched controls. Analysis of the temporal morphological profiles among them revealed the RGCs to have the earliest changes compared to the SC and LGN although the most prominent changes occurred in the SC. CONCLUSION: Our study has demonstrated that OHT results in dendritic changes of the neurons throughout the visual pathways, from RGCs to SC cells and LGN cells, suggesting that both the retina and the brain should be targeted when considering diagnosis and therapeutic strategies for glaucoma. |
| File Format | HTM / HTML |
| ISSN | 02713683 |
| Issue Number | 9 |
| Volume Number | 39 |
| e-ISSN | 14602202 |
| Journal | Current Eye Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Dendrites Pathology Disease Models, Animal Ocular Hypertension Retinal Ganglion Cells Visual Pathways Animals Geniculate Bodies Intraocular Pressure Male Microscopy, Confocal Rats Superior Colliculi Tonometry, Ocular Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Cellular and Molecular Neuroscience |
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