NDLI: The effect of intravitreal injection of bevacizumab on retinal circulation in patients with neovascular macular degeneration.

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The effect of intravitreal injection of bevacizumab on retinal circulation in patients with neovascular macular degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Olivier, Sébastien Fontaine, Olivier Lesk, Mark R. Descovich, Denise Cordahi, Ghassan Vaucher, Elvire
Description	Country affiliation: Canada Author Affiliation: Fontaine O ( Department of Ophthalmology, Faculty of Medicine, University of Montréal, Montréal, Quebec, Canada.)
Abstract	PURPOSE: Intravitreal (ITV) injection of anti-VEGFs like bevacizumab are widely used to treat neovascular AMD. However, VEGF is essential for biologic functions such as blood pressure regulation. Indeed, anti-VEGF intravenous administration is associated with hypertension. Therefore, the effect of ITV bevacizumab on retinal circulation was examined. METHODS: Twenty-three patients with neovascular AMD treated with three repeat ITV injections of bevacizumab were recruited. Blood arteriolar diameter and flow measurements were performed with a bidirectional laser Doppler flowmeter at baseline, 1 week after the first injection, just before the second injection, and 5 weeks after the third injection. Scanning laser Doppler flowmetry was used to assess the effect of bevacizumab on tissue perfusion at the first and fourth visits. RESULTS: Arteriolar diameter significantly decreased from 122.5 ± 14.5 µm to 118.9 ± 14.0 µm (P = 0.03) during the first week to reach a mean value of 117.2 ± 13.7 µm at the end of the study (P < 0.01). Arterial blood flow did not change significantly. Neuroretinal rim perfusion decreased from 181.1 ± 84.1 arbitrary flow units to 167.7 ± 76.5 arbitrary flow units, which was borderline significant (P = 0.06). No significant change was observed in the peripapillary retina. CONCLUSIONS: Arteriolar diameter decreased significantly after the first injection and persisted until the end of the study suggesting a long-term effect of bevacizumab on vascular tone. However, the blood flow change is not significant. A borderline significant decrease in neuroretinal rim perfusion was observed and suggests that the neuroretinal rim may be more sensitive than the peripapillary retina to the effects of bevacizumab.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Angiogenesis Inhibitors Administration & Dosage Antibodies, Monoclonal, Humanized Blood Circulation Drug Effects Retinal Artery Physiology Wet Macular Degeneration Physiopathology Bevacizumab Blood Flow Velocity Blood Pressure Intravitreal Injections Laser-doppler Flowmetry Muscle, Smooth, Vascular Metabolism Prospective Studies Retina Pathology Vascular Endothelial Growth Factor A Antagonists & Inhibitors Visual Acuity Drug Therapy Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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