NDLI: Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

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Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

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Gene expression profiling of the retina after transcorneal electrical stimulation in wild-type Brown Norway rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schäferhoff, Karin Naycheva, Lubka Fischer, Manuel D. Arango-Gonzalez, Blanca Zrenner, Eberhart Schatz, Andreas Bartz-Schmidt, Karl U. Bonin, Michael Willmann, Gabriel Röck, Tobias Gekeler, Florian Bolz, Sylvia
Description	Country affiliation: Germany Author Affiliation: Willmann G ( University Eye Hospital and Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.)
Abstract	PURPOSE: Transcorneal electrical stimulation (TES) has been beneficial in several neurodegenerative ocular diseases, but the exact mechanisms remain to be elucidated. This study was conducted to investigate the effects of TES on the retinas of wild-type Brown Norway (BN) rats by gene expression profiling and to assess its effects on retinal function and morphology. METHODS: TES was applied to BN wild-type rat retinas in vivo for 1 hour (1-ms biphasic pulses at 20 Hz; 200 µA). RNA was isolated and processed for microarray-based profiling 4 hours after TES; differentially expressed genes from TES compared with those from sham-treated animals were validated by quantitative real-time polymerase chain reaction. Furthermore, the effect of TES was assessed at the structural and functional levels using electroretinography, confocal scanning laser ophthalmoscopy, optical coherence tomography, and immunohistochemistry. RESULTS: Transcriptome changes associated with TES versus sham-stimulated BN wild-type retina were identified. Four hundred ninety genes were differentially expressed in TES and included potentially neuroprotective genes such as Bax or members of the tumor necrosis factor family (Tnfrsf11b, Tnrsf12a, Tnfsf13b, Tnfsf13). ERG recordings showed physiological retinal function after TES, and structural in vivo and ex vivo studies revealed intact retinal anatomy. CONCLUSIONS: These results demonstrate that TES applied to the retina of the wild-type BN rats induces distinct transcriptome level changes and may help in the understanding of the mechanisms underlying TES. In addition, TES treatment indicates no negative effect on structure and function of the wild-type BN retina up to 35 hours after application.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Electric Stimulation Gene Expression Profiling Gene Expression Regulation Physiology Oligonucleotide Array Sequence Analysis Retina Metabolism Animals Cornea Electroretinography Immunohistochemistry Rats, Inbred Bn Real-time Polymerase Chain Reaction Tomography, Optical Coherence Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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