NDLI: Insulin growth factor promotes human corneal fibroblast network formation in vitro.

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Insulin growth factor promotes human corneal fibroblast network formation in vitro.

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Insulin growth factor promotes human corneal fibroblast network formation in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mirshahi, Massoud Therwath, Amu Legeais, Jean Marc Benabbou, Nadia Ducros, Elodie Agra, Aureliou Berthaut, Alexandre Mirshahi, Pezhman
Description	Country affiliation: France Author Affiliation: Berthaut A ( INSERM (Institut National de la Santé et de la Recherche Médicale) UMRS (Unité Mixte de Recherche Scientifique) 872, Faculté de Médecine Paris VI, Paris, France.)
Abstract	PURPOSE: Corneal fibroblast cell (CFC) reticulation is involved in the structural development of corneal stroma and in wound healing. In an earlier paper, it was reported that the expression of VEGFR-1 by CFCs is related to their reticulogenic properties in vitro and decreases with the age of the donors. The present study was focused on the nonreticulogenic corneal fibroblast population and explored whether these cells can be induced to form cell networks in vitro. METHODS: The network formation was analyzed using an array of signaling pathway inhibitors: wortmannin for PI3 kinase, U0126 for MEK-1/2 kinase, Rottlerin for PKC, farnesyl transferase inhibitor (FTI-277) for Ras, and picropodophyllin (PPP) for IGFR-1. Among the several growth factors studied, IGF seemed to be crucial to cell network formation. The presence of IGF signaling was demonstrated using gene array analysis and was confirmed by RT-PCR and immunocytochemistry and by cell network formation on reduced synthetic basement membrane arrays. The pleiotropic effect of IGF-1 on the cells was analyzed by protein cytokine array. RESULTS: The genesis of reticulation was found to occur via MEK-1/2 and IGFR pathways, since inhibitors of these signaling pathways reduced or prevented cell network formation. The addition of exogenous IGF-1 generated a cell network structure in corneal fibroblasts obtained from healthy donors, indicating the involvement of IGF-1. CONCLUSIONS: IGF signaling and the MEK-1/2 pathway are involved in the cell network formation of corneal fibroblast cells from aged donors.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Corneal Keratocytes Cytology Corneal Stroma Insulin-like Growth Factor I Physiology Cell Movement Cells, Cultured Metabolism Cytokines Genetics Enzyme Inhibitors Pharmacology Fluorescent Antibody Technique, Indirect Map Kinase Kinase 1 Map Kinase Kinase 2 Map Kinase Signaling System Drug Effects Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Wound Healing Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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