NDLI: Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays.

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Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Grus, Franz H. Wiegand, Michaela Riechardt, Aline I. Boehm, Nils Pfeiffer, Norbert
Description	Country affiliation: Germany Author Affiliation: Boehm N ( Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.)
Abstract	PURPOSE: In the pathogenesis of keratoconjunctivitis sicca, immune processes are thought to play an important role. However, the exact details of the pathomechanisms are still unknown. In this study, the expression patterns of proinflammatory cytokines in the tears of patients with different subtypes of dry eye were analyzed. METHODS: One hundred forty-three subjects subdivided into healthy controls (CTRL, n = 38), patients with aqueous-deficient dry eye (DRYaq, n = 35), patients with changes of the lipid layer (DRYlip, n = 36), and patients with a combination of both (DRYaplip, n = 34) were examined. Expression patterns of proteins (e.g., IL-1ß, IL-6, ITNF- , and IFN-Î³) were examined using an advanced antibody microarray approach. RESULTS: Several highly significant differences in the cytokine levels of dry eye patients compared with healthy controls were detected. Patients with DRYaq or those with DRYaplip showed elevated levels for most of the tested proteins. For example, IL-1ß was found to be elevated 2.4-fold in DRYaq patients and 2.75-fold in DRYaqlip patients (both P < 8.00E-6). The detected amounts of protein in DRYlip patients and in healthy controls showed only minimal differences (fold increase/decrease for all proteins >1.2; P > 5.00E-1). CONCLUSIONS: The similarity between the profiles of healthy controls and DRYlip patients justifies the assumption that the pathomechanism of this dry eye subtype is based on mechanisms other than inflammation, whereas it seems to be the case for DRYaq patients.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-29
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dry Eye Syndromes Metabolism Eye Proteins Interferon-gamma Interleukin-1beta Interleukin-6 Tumor Necrosis Factor-alpha Adolescent Child, Preschool Classification Infant Protein Array Analysis Chemistry Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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