NDLI: Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication.

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Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Shao Zhen Yu, Shang Juan Koh, Siew Kwan Wong, Tina T. Zhou, Lei Tong, Louis Li, Xiao Rong Beuerman, Roger W. Li, Jing
Description	Country affiliation: Singapore Author Affiliation: Wong TT ( Singapore Eye Research Institute, Singapore. tina.wong.t.l@snec.com.sg)
Abstract	PURPOSE: To identify the tear proteins associated with the long-term use of glaucoma medication by using proteomic analysis and to compare these proteins to those previously reported in primary dry eye disease. METHODS: Eighteen patients treated with topical antiglaucoma medications and 10 normal age-matched subjects with no prior topical treatment were recruited for the study. Tears were collected by using Schirmer's strip and analyzed by iTRAQ (isobaric tag for relative and absolute quantitation) for tear proteins by mass spectrometry. Conjunctival samples were collected and RNA expression determined by PCR. RESULTS: Of the 124 identified tear proteins (99% confidence, ProtScore ≥ 2.0), we found that the tear levels of S100-A8, S100-A9, mammaglobin B, and 14-3-3 Î¶/Î´ were significantly increased in the medicated group compared with levels in the nonmedicated group (P < 0.05). For S100-A9, mammaglobin B, and 14-3-3 Î¶/Î´, use of topical medication for less than 1 year did not reach statistical significance compared with that in the nonmedicated group. Eyes on topical medication for less than 1 year showed a decrease in proline-rich 4 protein tear level (P = 0.0049) compared to nonmedicated group. The tear proteins detected in the medicated group differed from those in the primary dry eye group. CONCLUSIONS: Treatment with topical antiglaucoma medications for longer than 1 year may start to induce ocular surface inflammation. The inflammatory tear protein profile present in chronically medicated glaucomatous eyes appears to be different from that found in primary dry eye. Identification of tear proteins specific to medicated glaucomatous eyes will help to specifically develop targeted screening modalities and therapeutic agents different from current conventional dry eye management.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	52
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2011-09-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antihypertensive Agents Administration & Dosage Eye Proteins Genetics Gene Expression Profiling Gene Expression Regulation Physiology Glaucoma Metabolism Administration, Topical Blotting, Western Dry Eye Syndromes Expressed Sequence Tags Drug Therapy Peptide Fragments Protein Array Analysis Proteomics Reverse Transcriptase Polymerase Chain Reaction Tandem Mass Spectrometry Comparative Study Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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