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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Yueyun Wang, Yulan Wei, Qin Li, Faying Jiang, Liping Dong, Yunhui Han, Jian |
| Description | Author Affiliation: Li F ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.); Han J ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.); Jiang L ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.); Wang Y ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.); Li Y ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China. Electronic address: liyueyun71@163.com.); Dong Y ( School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.); Wei Q ( Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.) |
| Abstract | In this study, a novel and ultrasensitive sandwich-type electrochemical immunosensor was prepared for the quantitative detection of alpha fetoprotein (AFP), a well-known hepatocellular carcinoma biomarker. Gold nanoparticles (Au NPs) functionalized magnetic multi-walled carbon nanotubes (MWCNTs-Fe3O4) were prepared and utilized for the adsorption of lead ions (Pb(2+)) and the secondary antibodies (Ab2). The resultant nanocomposites (Pb(2+)@Au@MWCNTs-Fe3O4) were used as the label for signal amplification, showing better electrocatalytic activity towards the reduction of hydrogen peroxide (H2O2) than MWCNTs, MWCNTs-Fe3O4 or Au@MWCNTs-Fe3O4 due to the synergetic effect presented in Pb(2+)@Au@MWCNTs-Fe3O4. Moreover, Au NPs were electrodeposited on the surface of glassy carbon electrode (GCE) for the effective immobilization of primary antibodies (Ab1). Under the optimal conditions, a linear range from 10 fg/mL to 100 ng/mL and a detection limit of 3.33 fg/mL were obtained. The proposed electrochemical sandwich-type immunosensor shows high sensitivity, good selectivity and stability for the quantitative detection of AFP, holding a great potential in clinical and diagnostic applications. |
| ISSN | 09565663 |
| Volume Number | 68 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Metal Nanoparticles Chemistry Nanotubes, Carbon Alpha-fetoproteins Isolation & Purification Antibodies, Immobilized Electrochemical Techniques Gold Humans Hydrogen Peroxide Magnetics Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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