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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Escarpa, Alberto Martín, Aída Batalla, Pilar Hernández-Ferrer, Javier Martínez, María Teresa |
| Description | Country affiliation: Spain Author Affiliation: Martín A ( Departament of Anlytical Chemistry, Physical Chemistry and Chemical Engineering University of Alcalá, E-28871 Alcalá de Henares, Madrid, Spain.); Batalla P ( Departament of Anlytical Chemistry, Physical Chemistry and Chemical Engineering University of Alcalá, E-28871 Alcalá de Henares, Madrid, Spain.); Hernández-Ferrer J ( Instituto de Carboquímica ICB-CSIC, Miguel Luesma Castán, 4, 50018 Zaragoza, Spain.); Martínez MT ( Instituto de Carboquímica ICB-CSIC, Miguel Luesma Castán, 4, 50018 Zaragoza, Spain.); Escarpa A ( Departament of Anlytical Chemistry, Physical Chemistry and Chemical Engineering University of Alcalá, E-28871 Alcalá de Henares, Madrid, Spain. Electronic address: alberto.escarpa@uah.es.) |
| Abstract | In this work, a straightforward in-situ measurement of L and D-amino acids (AAs) has been developed using disposable graphene oxide nanoribbon (GON) screen printed electrodes. For that, we took advantage of the electroactivity of certain clinically relevant AAs, such as tyrosine (Tyr) and methionine (Met), which are involved in important bacterial diseases (Bacillus subtilis and Vibrio cholera, respectively). The strategy is based on a dual electrochemical and enzymatic approach. The D-AA with the class enzyme D amino acid oxidase (DAAO) generates H2O2. This H2O2 is simultaneously detected with the L-AA, electroactive molecule by differential pulse voltammetry (DPV). These GON disposable platforms use just 50 µL of sample and a total analysis time of 360 s. Both L and D enantiomers calibration and quantitative analysis were explored and were simultaneously detected with accuracy and precision in urine samples. Any interference of uric acid and other electroactive AAs was noticed. This proposed electrochemical GON-based enantiomeric bio-sensor becomes a highly promising tool as future point of care for fast and reliable early diagnosis of diseases related to the presence of D-AAs. |
| ISSN | 09565663 |
| Volume Number | 68 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Amino Acids Isolation & Purification Biosensing Techniques Graphite Chemistry Analysis Hydrogen Peroxide Nanotubes, Carbon Oxides Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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