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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | He, Sijing Wang, Qiyou Shi, Qiujia Yu, Yanyan Zhang, Lin Chen, Zuanguang |
| Description | Country affiliation: China Author Affiliation: He S ( School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.); Wang Q ( The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address: 1732259720@qq.com.); Yu Y ( School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.); Shi Q ( School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.); Zhang L ( School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.); Chen Z ( School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: chenzg@mail.sysu.edu.cn.) |
| Abstract | A novel, label-free and inherent electroactive redox immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) was proposed based on gold nanoparticles (AuNPs) and potassium ferricyanide-doped polyaniline (FC-PANI) nanoparticles. FC-PANI composite was synthesized via oxidative polymerization of aniline, using potassium ferricyanide (K3[Fe(CN)6]) as both oxidant and dopant. FC-PANI acting as the signal indicator was first fixed on a gold electrode (GE) to be the signal layer. Subsequently, the negatively charged AuNPs could be adsorbed on the positively charged FC-PANI modified GE surface by electrostatic adsorption, and then to immobilize CEA antibody (anti-CEA) for the assay of CEA. The CEA concentration was measured through the decrease of amperometric signals in the corresponding specific binding of antigen and antibody. The wide linear range of the immunosensor was from 1.0 pg mL(-1) to 500.0 ng mL(-1) with a low detection limit of 0.1 pg mL(-1) (S/N=3). The proposed method would have a potential application in clinical immunoassays with the properties of facile procedure, stability, high sensitivity and selectivity. |
| ISSN | 09565663 |
| Volume Number | 68 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Carcinoembryonic Antigen Isolation & Purification Immunoassay Methods Aniline Compounds Chemical Synthesis Chemistry Antibodies Immunology Chitosan Ferricyanides Gold Humans Limit Of Detection Metal Nanoparticles Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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