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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Piccoli, Julia P. Santos-Filho, Norival A. Santos, Adriano Cilli, Eduardo M. Bueno, Paulo R. |
| Description | Author Affiliation: Santos A ( Department of Physical Chemistry, Chemistry Institute, São Paulo State University (UNESP, Universidade Estadual Paulista), Nanobionics Research Group, 55 Prof. Francisco Degni Street, 14800-060 Araraquara, São Paulo, Brazil(2).); Piccoli JP ( Department of Physical Chemistry, Chemistry Institute, São Paulo State University (UNESP, Universidade Estadual Paulista), Nanobionics Research Group, 55 Prof. Francisco Degni Street, 14800-060 Araraquara, São Paulo, Brazil(2).); Santos-Filho NA ( Department of Physical Chemistry, Chemistry Institute, São Paulo State University (UNESP, Universidade Estadual Paulista), Nanobionics Research Group, 55 Prof. Francisco Degni Street, 14800-060 Araraquara, São Paulo, Brazil(2).); Cilli EM ( Department of Physical Chemistry, Chemistry Institute, São Paulo State University (UNESP, Universidade Estadual Paulista), Nanobionics Research Group, 55 Prof. Francisco Degni Street, 14800-060 Araraquara, São Paulo, Brazil(2).); Bueno PR ( Department of Physical Chemistry, Chemistry Institute, São Paulo State University (UNESP, Universidade Estadual Paulista), Nanobionics Research Group, 55 Prof. Francisco Degni Street, 14800-060 Araraquara, São Paulo, Brazil(2). Electronic address: prbueno@iq.unesp.br.) |
| Abstract | Early detection assays play a key role in the successful treatment of most diseases. Redox capacitive biosensors were recently introduced as a potential electroanalytical assay platform for point-of-care applications but alternative surfaces (besides a mixed layer containing ferrocene and antibody receptive component) for recruiting important clinical biomarkers are still needed. Aiming to develop alternative receptive surfaces for this novel electrochemical biosensing platform, we synthesized a ferrocene redox-tagged peptide capable of self-assembly into metallic interfaces, a potentially useful biological surface functionalization for bedside diagnostic assays. As a proof of concept we used C-reactive protein (CRP), as a model biomarker, and compared the obtained results to those of previously reported capacitive assays. The redox-tagged peptide approach shows a limit of detection of 0.8 nmol L(-1) (same as 94 ng mL(-1)) and a linear range (R(2)â ¼98%) with the logarithm of the concentration of the analyte comprising 0.5-10.0 nmol L(-1), within a clinical relevant range for CRP. |
| ISSN | 09565663 |
| Volume Number | 68 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques C-reactive Protein Isolation & Purification Chemistry Humans Limit Of Detection Oligopeptides Oxidation-reduction Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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