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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vezouviou, Evangelia Lowe, Christopher R. |
| Description | Author Affiliation: Vezouviou E ( Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB21QT, UK. Electronic address: Evangelia.vezouviou@cantab.net.); Lowe CR ( Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB21QT, UK.) |
| Abstract | Real-time glucose monitoring has been beneficial in reducing health complications associated with diabetes as well as a decrease in mortality. This report describes a novel holographic platform, fabricated via laser ablation on chitosan hydrogel with gold nanoparticles with a replaying in visible and near IR. The sensor responded with a 12 nm and 7 nm shift in wavelength at glucose concentrations in the 0-70 mM range and in the visible and near IR, respectively, at pH 7.4 and an ionic strength of 154 mM. The sensor did not respond to potential interferences found in the interstitial fluid, such as fructose, vitamin C and lactate, at their respective normal concentrations and was stable to fluctuations in temperature, pH and ionic strength. The characteristics of this sensor suggests that it may be applicable for use as an implanted device for the real time monitoring of glucose concentrations in the interstitial fluid using near IR as the interrogating medium. |
| ISSN | 09565663 |
| Volume Number | 68 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-06-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biosensing Techniques Instrumentation Chitosan Chemistry Glucose Analysis Holography Benzaldehydes Boronic Acids Extracellular Fluid Gold Humans Hydrogel Infrared Rays Lasers Light Metal Nanoparticles Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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