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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Porter, Graham Chilvers, Geoffrey Spencer |
| Description | Author Affiliation: Chilvers GS ( ENT Department, St Michael's Hospital, University Hospitals Bristol Trust, Bristol, UK.); Porter G ( ENT Department, St Michael's Hospital, University Hospitals Bristol Trust, Bristol, UK.) |
| Abstract | This is the first case report of a patient with acquired von Willebrand's disease (AvWD) secondary to epithelial myoepithelial carcinoma (EMC) of the parotid salivary gland. This patient presented to haematology following an abnormal bleeding episode with von Willebrand factor Ristocetin cofactor (VWF:RCo) <5% and VWF:Ag 13%. He was diagnosed with AvWD. At the same time he was found to have a left parotid lump which was excised following a multidisciplinary team meeting. This was histologically reported as an EMC. Following excision, unusually this patient's AvWD did not resolve. Extensive investigation looking for other causes of the AvWD did not reveal any other potential cause; therefore, due to the similar timing of onset of both pathologies it is felt that the AvWD in this case is secondary to the EMC. This case report highlights the presentation, investigation and management of AvWD and parotid lumps as well as discussing proposed pathophysiological mechanisms for AvWD. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Neoplasms, Glandular And Epithelial Complications Parotid Neoplasms Von Willebrand Diseases Etiology Diagnosis, Differential Magnetic Resonance Imaging Diagnosis Surgery Blood Von Willebrand Factor Metabolism Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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