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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martinelli, Vittorio Rodegher, Mariaemma Messina, Maria Josè Scotti, Roberta |
| Description | Author Affiliation: Messina MJ ( Department of Neurology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.); Rodegher M ( Department of Neurology, San Raffaele Scientific Institute, Milan, Italy.); Scotti R ( Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy.); Martinelli V ( Department of Neurology, San Raffaele Scientific Institute, Milan, Italy.) |
| Abstract | Behçet's disease (BD) is a chronic inflammatory disorder that involves the parenchymal central nervous system (neuro-BD, NBD) approximately in 5-49% of patients, causing lesions rarely located in the spinal cord (SC). We report the first case of NBD-myelitis treated with intravenous rituximab. A 41-year-old man affected by BD presented with mild paraparesis with a miliary involvement and a 'net-like' gadolinium enhancement (Gde) of the SC. After a therapeutic attempt with pulsed cyclophosphamide and intravenous methylprednisolone, the clinical and neuroradiological course worsened. A progressive improvement was observed after rituximab administration associated with low doses of oral prednisone. No disease activity was detected and the patient reported no adverse event. After six rituximab cycles, cervical MRI was normal while thoracic MRI showed a slight T2-weighted hyperintensity of D4-D10 spinal tract without Gde. A combined use of rituximab and oral steroids resulted in a long-term suppression of NBD activity without any safety concern. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Monoclonal, Murine-Derived Therapeutic Use Behcet Syndrome Complications Immunologic Factors Myelitis Etiology Administration, Intravenous Administration & Dosage Diagnosis Diagnosis, Differential Magnetic Resonance Imaging Drug Therapy Rituximab Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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