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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dhakal, Mona Bhandari, Dhurba Dhakal, Om Prakash |
| Description | Author Affiliation: Dhakal OP ( Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.); Dhakal M ( Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.); Bhandari D ( Department of Microbiology, SMIMS and CRH, Gangtok, Sikkim, India.) |
| Abstract | Domperidone is a commonly prescribed antiemetic drug but its side effects are rarely seen. Extrapyramidal side effects are a very rare complication of the drug occurring in 1/10,000 population. They usually occur in infants and very young children due to a poorly developed blood-brain barrier. We report a case of acute dystonia in a 13-year-old boy induced by domperidone. The boy was treated for viral fever and was started on domperidone 30â mg/day, sustained release form (0.7â mg/kg/day), for persistent vomiting along with other supportive treatment. On the fourth day of treatment, although the fever and vomiting subsided, the child developed oromandibular dystonia despite giving the drug in the recommended dose. Fortunately, drug-induced dystonias are a reversible condition and the child improved in 7-8â days after discontinuation of the drug. There was no recurrence at 1â month follow-up. Usually, dystonic reactions do not threaten life but are troublesome and life altering, so judicious use of the drug is advised. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antiemetics Adverse Effects Domperidone Dystonia Chemically Induced Adolescent Therapeutic Use Vomiting Drug Therapy Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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