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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carter, Erin E. Kline, Gregory |
| Description | Author Affiliation: Carter EE ( Department of Medicine, University of Calgary, Calgary, Canada.) |
| Abstract | A 42-year-old man diagnosed with pseudohypoparathyroidism and Albright's hereditary osteodystrophy as an infant was lost to follow-up and remained, unmonitored, on calcitriol and calcium for over 20 years. He presented after having an ST-elevation myocardial infarction. In addition to coronary artery calcifications, he was found to have diffuse subcutaneous and joint calcifications. His calcium, phosphate and parathyroid hormone (PTH) levels were normal, and given the lack of prior documentation in the diagnosis he was instructed to discontinue calcitriol and calcium until further investigations were completed. Despite stopping the medication, his serum calcium remained normal for over 1 year. It was not until 18 months later, when his soft tissue calcium stores were depleted, that he finally developed symptomatic hypocalcaemia and an elevated PTH. This case not only emphasises the importance of long-term follow-up for patients with pseudohypoparathyroidism, but also highlights the potential complications of long-term, unmonitored, calcitriol use. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Calcitriol Adverse Effects Calcium Coronary Artery Disease Etiology Myocardial Infarction Pseudohypoparathyroidism Drug Therapy Vascular Calcification Calcinosis Hypocalcemia Joint Diseases Lost To Follow-Up Parathyroid Hormone Blood Complications Subcutaneous Tissue Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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