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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hirota, Keisho Yasoda, Akihiro Inagaki, Nobuya Fujii, Toshihito |
| Description | Author Affiliation: Hirota K ( Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.) |
| Abstract | A 52-year-old woman with overlap syndrome and interstitial pneumonia underwent immunosuppressive therapy and she was suspected to suffer from pulmonary aspergillosis. Oral voriconazole was initiated, and a rapid elevation of alkaline phosphatase (ALP) occurred after 4 weeks. After 2 months, the patient presented diffuse pain in bilateral skeletal regions, and bone scintigraphy revealed bilateral multiple areas of increased radiotracer uptake. We suspected the skeletal involvement as voriconazole-induced periostitis. Actually, the plasma fluoride level was increased. Voriconazole was replaced with itraconazole, and after 3 weeks, the patient stopped complaining of bone pain concomitant with the decrease in ALP. Voriconazole-induced periostitis is a rare condition but had previously been reported in solid organ or patients with bone marrow transplant who received a long-term voriconazole therapy. Our present case is distinctive of previous ones, because it occurred in a patient with connective tissue disease which had its rapid progression. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antifungal Agents Adverse Effects Periostitis Chemically Induced Pulmonary Aspergillosis Drug Therapy Rheumatic Diseases Complications Voriconazole Therapeutic Use Immunocompromised Host Immunosuppressive Agents Diagnosis Immunology Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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