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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sandoval, Mark Anthony Santiago Bautista, Aileen Azul Duya, Jose Eduardo De Leon |
| Description | Author Affiliation: Bautista AA ( Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, Manila, Philippines.); Duya JE ( Department of Medicine, Philippine General Hospital, Manila, Philippines.); Sandoval MA ( Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, Manila, Philippines.) |
| Abstract | A 35-year-old man presented with recurrent lower extremity weakness associated with polyuria later progressing to generalised weakness with difficulty in breathing. The patient was hypotensive and dry, with normal thyroid and chest examination, weak lower extremity and carpopedal spasm. Workup revealed hypokalaemia, hyponatraemia, hypocalcaemia, hypomagnesaemia, hypochloraemia and hypophosphataemia. Arterial blood gas showed respiratory alkalosis with good oxygenation. Twenty-four-hour urine collection showed normal volume with electrolyte wasting. Thyroid function test revealed overt hypothyroidism with negative antithyroid peroxidase. The patient was well after treatment with levothyroxine, volume and electrolyte replacement and was discharged. Thyroid hormones are related to the expression of the Na-K-ATPase, Na-Pi cotransporter, Mg-ATPase and Na-Ca exchanger pumps in the renal tubules. Sodium, potassium, phosphate, calcium, magnesium and water losses result from decreased expression of these pumps. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Hypothyroidism Complications Muscle Weakness Etiology Respiratory Tract Diseases Hypocalcemia Hypokalemia Hyponatremia Hypophosphatemia Diagnosis Kidney Diseases Physiopathology Lower Extremity Recurrence Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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