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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tanaka, Akira Kuramitsu, Shoichi Fukuyama, Keita Fujikawa, Takahisa |
| Description | Author Affiliation: Fukuyama K ( Department of Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan.) |
| Abstract | We report a case of a 69-year-old man who started dual antiplatelet therapy (APT) with aspirin and clopidogrel after recent implantation of drug-eluting coronary stent and developed massive bleeding due to large duodenal gastrointestinal stromal tumour (GIST). Following endoscopic haemostasis and discontinuation of dual APT, neoadjuvant chemotherapy with imatinib was started under continuation of 'single' APT with aspirin. A good chemotherapeutic response was achieved without recurrence of bleeding, and subsequent less invasive surgical resection of the tumour was performed, while preoperative single APT was continued for prevention of stent thrombosis. The patient recovered well without any thromboembolic or bleeding events. Neoadjuvant imatinib therapy and subsequent less invasive surgery under continuation of APT is one of the preferred approaches for patients with duodenal GIST with severe thromboembolic comorbidities, as in the current case. |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Volume Number | 2014 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Aspirin Adverse Effects Duodenal Neoplasms Complications Gastrointestinal Hemorrhage Etiology Therapy Gastrointestinal Stromal Tumors Platelet Aggregation Inhibitors Ticlopidine Analogs & Derivatives Benzamides Therapeutic Use Chemotherapy, Adjuvant Coronary Stenosis Drug-Eluting Stents Drug Therapy Surgery Hemostatic Techniques Imatinib Mesylate Neoadjuvant Therapy Piperazines Pyrimidines Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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