NDLI: On the evolution of accuracy and cost of proofreading tRNA aminoacylation.

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On the evolution of accuracy and cost of proofreading tRNA aminoacylation.

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On the evolution of accuracy and cost of proofreading tRNA aminoacylation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Freter, R. R. Savageau, M. A.
Abstract	Aminoacylation of tRNA occurs with a high degree of accuracy in many cases because misacylated molecules are effectively proofread on the aminoacyl-tRNA synthetase by preferential hydrolysis. This hydrolysis releases an ATP equivalent of energy. An explicit relationship between cost of proofreading and the resulting degree of accuracy is presented. Experimental data from Escherichia coli for isoleucyl-tRNA synthetase proofreading valyl-tRNAIle are examined by means of this relationship, and a conjecture concerning the natural selection of accuracy and proofreading costs is put forth and tested. We have found the energy cost of accurate proofreading to be high. The minimum error, derived in previous theoretical studies, is never actually reached. Instead, higher values, determined by the balance between energy wasted in the cell as a consequence of error and the energy cost of proofreading, appear to be selected. The total cost of proofreading all types of tRNA aminoacylations is estimated to be approximately 2% of the energy required to synthesize a bacterial cell.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amino Acyl-tRNA Synthetases Metabolism Escherichia Coli Enzymology Energy Metabolism Genetics Isoleucine-tRNA Ligase RNA, Transfer Selection, Genetic Substrate Specificity Valine Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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