NDLI: Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts.

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Photoelectric properties and detection of the aromatic carcinogens benza[a]pyrene and dimethylbenzanthracene.

Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of β-galactosidase by fibroblasts

Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.

Promoter mutations in the transfer RNA gene tyrT of Escherichia coli.

Passive modulation of blood-group antigens.

Immunoglobulin differentiation is dictated by repeated recombination sequences within the V region prototype gene: a hypothesis.

Some sequence similarities among cloned mouse DNA segments that code for lambda and kappa light chains of immunoglobulins.

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome.

Cloning of the structural gene (ompA) for an integral outer membrane protein of Escherichia coli K-12.

Cloning of integrated Moloney sarcoma proviral DNA sequences in bacteriophage lambda.

Isolation of glycosaminoglycans (heparan sulfate) from glomerular basement membranes.

Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequences.

Transcription promotes recA-independent recombination mediated by DNA-dependent RNA polymerase in Escherichia coli.

Sigma subunit of Escherichia coli RNA polymerase affects the function of lambda N gene.

Bacterial lipopolysaccharide activates suppressor B lymphocytes.

Photoaffinity labeling of cyclic-AMP- and AMP-binding proteins differentiating Dictyostelium discoideum cells.

Enzymatic methyl esterification of specific glutamyl residue in corticotropin.

Characterization of a histone-like protein extracted from yeast mitochondria.

Oncogenicity of simian virus 40 deletion mutants that induce altered 17-kilodalton t-proteins.

A general priming system employing only dnaB protein and primase for DNA replication.

Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.

Conserved primary sequences of the DNA terminal proteins of five different human adenovirus groups.

DNA synthesis in temperature-sensitive mutants of the cell cycle infected by polyoma virus and adenovirus.

Phospholipid methylation stimulates lactogenic binding in mouse mammary gland membranes.

Molecular genetics of herpes simplex virus: the terminal a sequences of the L and S components are obligatorily identical and constitute a part of a structural gene mapping predominantly in the S component.

Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

Catabolite inactivation of gluconeogenic enzymes in mutants of yeast deficient in proteinase B.

Selective and unidirectional membrane redistribution of an H-2 antigen with an antibody-clustered viral antigen: relationship to mechanisms of cytotoxic T-cell interactions.

Sodium transport inhibitor from bovine hypothalamus.

Endogenous digitalis-like activity in mammalian brain.

1H nuclear magnetic resonance investigation of flexibility in DNA.

Antibodies bound to lipid haptens in model membranes diffuse as rapidly as the lipids themselves.

Characterization of an endopeptidase involved in pre-protein processing.

Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus.

Synthesis of fluorescent nucleotide analogues: 5'-mono-, di-, and triphosphates of linear-benzoguanosine, linear-benzoinosine, and linear-benzoxanthosine.

Differential activities of glycolipid glycosyltransferases in Tay-Sachs disease: studies in cultured cells from cerebrum.

Mechanism for circularization of linear DNAs: circular parvovirus MVM DNA is formed by a 'noose' sliding in a 'lasso'-like DNA structure.

Structure of genes for human growth hormone and chorionic somatomammotropin.

Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts.

Identification of gamma-glutamyl phosphate in the alpha 2 chains of chicken bone collagen.

Comparison of adult, embryonic, and dystrophic myosin heavy chains from chicken muscle by sodium dodecyl sulfate/polyacrylamide gel electrophoresis and peptide mapping.

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Construction and cloning of rat albumin structural gene sequences.

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Protein-heme interaction in hemoglobin: evidence from Raman difference spectroscopy.

Filament interaction in intact muscle fibers monitored by light scattering.

Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth.

Presence and expression of Friend erythroleukemia virus-related sequences in normal and leukemic mouse tissues.

Acute stimulation of aromatization in Leydig cells by human chorionic gonadotropin in vitro.

Regulation of translational initiation ina temperature-sensitive mutant of BHK cells.

Stimulation of phospholipid metabolism in embryonic muscle cells treated with phospholipase C.

Isolation of a high molecular weight actin-binding protein from baby hamster kidney (BHK-21) cells.

Fluorescent phallotoxin, a tool for the visualization of cellular actin.

Biological detection of specific mRNA molecules by microinjection.

Murine erythroleukemia cell differentiation: relationship of globin gene expression and of prolongation of G1 to inducer effects during G1/early S.

Calculation of evolutionary trees from sequence data.

Polymorphism and loss of duplicate gene expression: a theoretical study with application of tetraploid fish.

Cytoplasmic inheritance of erythromycin resistance in human cells.

Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.

DNA restriction endonuclease analysis for localization of human beta- and delta-globin genes on chromosome 11.

Telomere replication, kinetochore organizers, and satellite DNA evolution.

Cell cytotoxicity due to specific influenza antibody production in vitro after recent influenza antigen stimulation.

Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

Studies on murine Ss protein: demonstration that S region encodes structural gene for fourth component of complement.

Apolipoproteins in human cerebrospinal fluid.

Cholesterol homeostasis in the rat with a portacaval anastomosis.

Restriction endonuclease cleavage map and location of unique features of the DNA of hepatitis B virus, subtype adw2.

Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents.

Target recognition in neurogenesis: formation of the Mauthner axon cap.

Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset.

Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans.

'Hybrid' synapses formed by foreign innervation of parasympathetic neurons: a model for selectivity during competitive reinnervation.

Differences in mutagenicity and cytotoxicity of (+)- and (-)-benzo[a]pyrene 4,5-oxide: a synergistic interaction of enantiomers.

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Energy-dependent processing of cytoplasmically made precursors to mitochondrial proteins.

Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from Escherichia coli.

Accessibility of guanine at position 44 in the invariant sequence 5'CCG44AAC3' of Escherichia coli 5S RNA to reaction with kethoxal.

On the evolution of accuracy and cost of proofreading tRNA aminoacylation.

Genetics of type II glycogenosis: assignment of the human gene for acid alpha-glucosidase to chromosome 17.

Activation of mating type genes by transposition in Saccharomyces cerevisiae.

Evidence that a single DNA ligase is involved in replication and recombination in yeast.

Enhanced mitotic recombination in a ligase-defective mutant of the yeast Saccharomyces cerevisiae.

Characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum

pH-dependent migration of copper(II) to the vacant zinc-binding site of zinc-free bovine erythrocyte superoxide dismutase

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

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A new glnA-linked regulatory gene for glutamine synthetase in Escherichia coli.

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Requirement for membrane potential in injection of phage T4 DNA.

Clonal hybrid cell lines expressing cholinergic and adrenergic properties.

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Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo.

Conformation of gramicidin A channel in phospholipid vesicles: a 13C and 19F nuclear magnetic resonance study.

Characterization of alkylamine-sensitive site in alpha 2-macroglobulin.

Trace polypeptides in cellular extracts and human body fluids detected by two-dimensional electrophoresis and a highly sensitive silver stain.

Synthesis of a 600-nucleotide-long plus-strand DNA by virions of Moloney murine leukemia virus.

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures.

Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells.

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Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chi, M. M. Sly, W. S. Natowicz, M. R. Lowry, O. H.
Abstract	Human beta-glucuronidase (beta-D-glucuronide glucuronosohydrolase, EC 3.2.1.31), like many other glycoprotein lysosomal hydrolases, is subject to receptor-mediated endocytosis by fibroblasts. Prior work demonstrated charge heterogeneity in beta-glucuronidase and showed that high-uptake forms are more acidic than slowly internalized forms. Considerable indirect evidence implicated mannose 6-phosphate as an essential part of the recognition marker on high-uptake enzyme forms. Here we report the purification of beta-glucuronidase from human spleen and demonstrate enzymatically that mannose 6-phosphate is released on acid hydrolysis of pure enzyme varies directly with its susceptibility to pinocytosis by fibroblasts. Enzyme forms resolved by CM-Sephadex chromatography differed over an 18-fold range in uptake rate and in mannose 6-phosphate content. The most acidic forms had 4.4 mol of mannose 6-phosphate per mol of enzyme. The mannose 6-phosphate was released from the enzyme by treatment with endoglycosidase H with concomitant loss of susceptibility to adsorptive endocytosis. Thus, these studies provide direct evidence that mannose 6-phosphate is present on high-uptake enzyme forms, that it is present in the recognition marker for uptake, and that it is present on oligosaccharide that is released by endoglycosidase H.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glucuronidase Metabolism Hexosephosphates Physiology Mannosephosphates Pinocytosis Receptors, Drug Biological Transport, Active Fibroblasts Glycoproteins Glycoside Hydrolases Spleen Enzymology Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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