NDLI: Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of β-galactosidase by fibroblasts

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Photoelectric properties and detection of the aromatic carcinogens benza[a]pyrene and dimethylbenzanthracene.

Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of β-galactosidase by fibroblasts

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Passive modulation of blood-group antigens.

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Some sequence similarities among cloned mouse DNA segments that code for lambda and kappa light chains of immunoglobulins.

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome.

Cloning of the structural gene (ompA) for an integral outer membrane protein of Escherichia coli K-12.

Cloning of integrated Moloney sarcoma proviral DNA sequences in bacteriophage lambda.

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Sigma subunit of Escherichia coli RNA polymerase affects the function of lambda N gene.

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Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40.

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DNA synthesis in temperature-sensitive mutants of the cell cycle infected by polyoma virus and adenovirus.

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Selective and unidirectional membrane redistribution of an H-2 antigen with an antibody-clustered viral antigen: relationship to mechanisms of cytotoxic T-cell interactions.

Sodium transport inhibitor from bovine hypothalamus.

Endogenous digitalis-like activity in mammalian brain.

1H nuclear magnetic resonance investigation of flexibility in DNA.

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Characterization of an endopeptidase involved in pre-protein processing.

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Structure of genes for human growth hormone and chorionic somatomammotropin.

Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts.

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Biological detection of specific mRNA molecules by microinjection.

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Target recognition in neurogenesis: formation of the Mauthner axon cap.

Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset.

Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans.

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

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Enhanced mitotic recombination in a ligase-defective mutant of the yeast Saccharomyces cerevisiae.

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Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo.

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Trace polypeptides in cellular extracts and human body fluids detected by two-dimensional electrophoresis and a highly sensitive silver stain.

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Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

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Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of β-galactosidase by fibroblasts

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hieber, V. Distler, J. Jourdian, G. W. Sahagian, G. Schmickel, R.
Abstract	Bovine testicular beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) is rapidly and selectively assimilated by human skin fibroblasts. The assimilation of the enzyme is strongly inhibited by mannose 6-phosphate and by a glycoprotein fraction isolated from bovine testes (glycoprotein inhibitors). These results suggest that beta-galactosidase and the glycoprotein inhibitors have a common recognition marker that contains mannose 6-phosphate. The presence of mannose phosphate in the glycoprotein inhibitors was demonstrated by acid hydrolysis of the glycoproteins to liberate mannose phosphate followed by reduction with NaB(3)H(4) to give [(3)H]mannitol phosphate. The (3)H-labeled compound was identified by paper electrophoresis and by the release of [(3)H]mannitol on treatment with phosphatase. The [(3)H]mannitol phosphate was oxidized with periodate and the resulting phosphorylated fragment, on reduction with NaB(3)H(4), yielded [(3)H]ethylene glycol phosphate, indicating substitution of phosphate on carbon 6 of mannitol. Mannose 6-phosphate was also found in a major carbohydrate-containing fraction of peptides produced from the glycoprotein inhibitors by tryspin digestion. It was estimated that about 2% of the mannose residues were present as mannose 6-phosphate. Phosphorylated oligosaccharides were also identified in hydrolysates of the glycoprotein inhibitors. One, a disaccharide, was identified as alpha-(mannosyl-6-phosphate)-(1 --> 2)-mannose. These observations suggest that the recognition marker of beta-galactosidase contains alpha1,2-linked mannose 6-phosphate; terminal alpha1,2-linked mannose residues are known to occur in the high-mannose type oligosaccharides present on beta-galactosidase.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fibroblasts Metabolism Galactosidases Glycoproteins Pharmacology Hexosephosphates Mannosephosphates Beta-Galactosidase Carrier Proteins Peptide Fragments Receptors, Drug Structure-Activity Relationship Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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