NDLI: Transcriptional 'silencer' element in rat repetitive sequences associated with the rat insulin 1 gene locus.

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Transcriptional 'silencer' element in rat repetitive sequences associated with the rat insulin 1 gene locus.

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Transcriptional 'silencer' element in rat repetitive sequences associated with the rat insulin 1 gene locus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Laimins, L. Holmgren-könig, M. Khoury, G.
Abstract	The enhancer elements from either simian virus 40 or murine sarcoma virus activate the expression of a transfected rat insulin 1 (rI1) gene when placed within 2.0 kilobases or less of the rI1 gene cap site. Inclusion of 4.0 kilobases of upstream rI1 sequence, however, results in a substantial reduction in the enhancer-dependent insulin gene expression. These observations suggested that a negative transcriptional regulatory element was present between 2.0 and 4.0 kilobases of the rI1 sequence. To test this notion, we employed a heterologous enhancer-dependent transcription assay in which the simian virus 40 72-base-pair repeat is linked to a human beta-globin gene. Addition of the upstream rI1 element to this system decreased the level of enhancer-dependent beta-globin transcription by a factor of 5 to 15. This rI1 'silencer' element functions in a manner relatively independent of position and orientation and requires a cis-dependent relationship to the transcription unit on which it acts. Thus, the silencer sequence seems to have a number of the characteristics of enhancer elements, and we suggest that it may function by the converse of the enhancer mechanism. The rI1 silencer sequence was identified as a member of a long interspersed rat repetitive family. Thus, a potential role for certain repetitive sequences interspersed throughout the eukaryotic genome may be to regulate gene expression by retaining transcriptional activity within defined domains.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Regulator Insulin Genetics Repetitive Sequences, Nucleic Acid Animals Cercopithecus Aethiops DNA, Recombinant Enhancer Elements, Genetic Gene Expression Regulation Globins L Cells (Cell Line) Mice Simian Virus 40 Transcription, Genetic Transfection Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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