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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fagarasan, M. O. Eskay, R. Axelrod, J. |
| Description | Author Affiliation: Fagarasan MO ( National Institute on Alcohol Abuse and Alcoholism, Laboratory of Metabolism and Molecular Biology, Bethesda, MD 20892.); |
| Abstract | Previous work has shown that corticotropin releasing factor, vasoactive intestinal peptide, phorbol ester, and forskolin cause the secretion of adrenocorticotropic hormone and beta-endorphin from the AtT-20 mouse pituitary cell line. Human recombinant interleukin 1 alpha and 1 beta also stimulated adrenocorticotropic hormone and beta-endorphin secretion from AtT-20 cells in a time- and dose-related manner. The effect appeared only after pretreatment with interleukin 1 (IL-1) for at least 18 hr and was maximum at 24 hr. After pretreatment of the cells over a period of time with IL-1, the secretion induced by corticotropin releasing factor and vasoactive intestinal peptide was increased in more than an additive manner. The enhancement of corticotropin releasing factor-induced beta-endorphin release produced by IL-1 was apparent after 12 hr and reached a maximum at 24 hr. IL-1 did not affect forskolin-induced cAMP generation but enhanced the effect of forskolin on beta-endorphin secretion. This suggests that IL-1 does not induce adenylate cyclase and that forskolin causes the secretion of beta-endorphin by a mechanism independent of cAMP. IL-1 enhanced phorbol ester-induced beta-endorphin secretion. After prolonged treatment with phorbol ester (an activator of protein kinase C), the secretion induced by phorbol ester was abolished as well as the enhancement induced by IL-1. However, prolonged treatment with phorbol ester had no effect on IL-1-induced beta-endorphin secretion. These observations suggest that IL-1 enhances peptide-generated secretion of beta-endorphin by inducing protein kinase C. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Interleukin-1 Pharmacology Beta-Endorphin Secretion Animals Colforsin Corticotropin-Releasing Hormone Cyclic AMP Biosynthesis Drug Synergism Enzyme Activation Drug Effects Kinetics Mice Pituitary Neoplasms Protein Kinase C Metabolism Recombinant Proteins Tetradecanoylphorbol Acetate Tumor Cells, Cultured Vasoactive Intestinal Peptide Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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