NDLI: Immunoglobulin receptor signaling depends on the carboxyl terminus but not the heavy-chain class.

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Immunoglobulin receptor signaling depends on the carboxyl terminus but not the heavy-chain class.

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Immunoglobulin receptor signaling depends on the carboxyl terminus but not the heavy-chain class.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Webb, C. F. Tucker, P. W. Nakai, C.
Description	Author Affiliation: Webb CF ( Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.);
Abstract	To examine the isotypic and structural requirements involved in signaling through the immunoglobulin (Ig) receptor on B lymphocytes, we established a panel of T15 idiotype-positive transfectants that expressed wild-type IgM, wild-type IgD, or hybrid IgM molecules. Growth inhibition of the transfected lymphoma cells in response to anti-idiotype antibodies was used to measure signaling. Hybrid IgM molecules were constructed so that the membrane-spanning region of the mu heavy chain was replaced by that of delta, gamma 2b, or alpha heavy chains or that of the I-Ab class II (Ia) alpha chain. All transfectants that expressed IgM or hybrid IgM molecules with membrane-spanning regions from another Ig isotype underwent signaling in response to anti-idiotype antibodies, whereas the IgM-Ia hybrid transfectants did not. Transfectants that expressed wild-type IgD molecules also underwent signaling, although this response was particularly sensitive to serum concentrations. These results imply that signaling occurs in a similar manner through heavy-chain receptors of any isotype and suggest that conserved amino acid sequences in the transmembrane regions are important in this process.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Immunoglobulin Heavy Chains Receptors, Immunologic Signal Transduction Amino Acid Sequence Animals Cell Division Cloning, Molecular Fluorescent Antibody Technique Histocompatibility Antigens Class II Genetics Immunoglobulin D Immunoglobulin Idiotypes Immunoglobulin Isotypes Immunoglobulin M Lymphoma Mice Molecular Sequence Data Plasmids Structure-Activity Relationship Transfection Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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