NDLI: Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

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Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

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Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chan, B. L. Saltiel, A. R. Chao, M. V.
Description	Author Affiliation: Chan BL ( Laboratory of Viral Oncology, Rockefeller University, New York, NY.);
Abstract	Treatment of PC-12 pheochromocytoma cells with nerve growth factor (NGF) results in the differentiation of these cells into a sympathetic neuron-like phenotype. Although the initial intracellular signals elicited by NGF remain unknown, some of the cellular effects of NGF are similar to those of other growth factors, such as insulin. We have investigated the involvement of a newly identified inositol-containing glycolipid in signal transduction for the actions of NGF. NGF stimulates the rapid generation of a species of diacylglycerol that is labeled with [3H]myristate but not with [3H]arachidonate. NGF stimulates [3H]myristate- or [32P]phosphate-labeled phosphatidic acid production over the same time course. Although NGF alone has no effect on the turnover of inositol phospholipids, it does stimulate the hydrolysis of glycosylphosphatidylinositol. The NGF-dependent cleavage of this lipid is accompanied by an increase in the accumulation of its polar head group, an inositol phosphate glycan, which is generated within 30-60 sec of NGF treatment. In an unresponsive PC-12 mutant cell line, neither the diacylglycerol nor inositol phosphate glycan response is detected. A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adrenal Gland Neoplasms Metabolism Glycolipids Nerve Growth Factors Pharmacology Pheochromocytoma Phosphatidylinositols Protein Kinase C Alkaloids Animals Arachidonic Acid Arachidonic Acids Diglycerides Biosynthesis Gene Expression Regulation Drug Effects Glycosylphosphatidylinositols Hydrolysis Myristic Acid Myristic Acids Phosphates Phosphatidic Acids Polysaccharides Proto-Oncogene Proteins Genetics Proto-Oncogene Proteins C-fos Receptors, Cell Surface Physiology Receptors, Nerve Growth Factor Signal Transduction Staurosporine Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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