NDLI: Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum.

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Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum.

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Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Radolf, J. D. Norgard, M. V. Schulz, W. W.
Description	Author Affiliation: Radolf JD ( Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.);
Abstract	Freeze fracture and deep etching were used to investigate the ultrastructural basis for the observation that anti-treponemal antibodies bind poorly to the surface of virulent Treponema pallidum. Fractures of T. pallidum outer membranes contained scarce, uniformly sized intramembranous particles (IMPs). IMPs on the convex faces often appeared to form linear arrays that wound in spirals about the organism. In contrast to the outer membrane, IMPs of the cytoplasmic membrane were randomly distributed, numerous, and heterogeneous in size. In Escherichia coli and T. pallidum cofractures, IMPs of the E. coli outer membranes were densely packed within the concave fracture faces, while the T. pallidum fractures were identical to the experiments lacking the E. coli internal controls. Outer membranes of two representative nonpathogenic treponemes, Treponema phagedenis biotype Reiter and Treponema denticola, contained numerous IMPs, which segregated preferentially with the concave halves. Examination of apposed replicas and deep-etched specimens indicated that at least some of the IMPs extend through the T. pallidum outer membrane and are exposed on the surface of the organism. The outer membrane of intact T. pallidum appears to contain a paucity of integral membrane proteins that can serve as targets for specific antibodies. These findings appear to represent an unusual parasitic strategy for evasion of host humoral defenses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Immunology Cell Membrane Ultrastructure Treponema Pallidum Escherichia Coli Freeze Etching Freeze Fracturing Microscopy, Electron Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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