NDLI: Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin.

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Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin.

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Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tirrell, S. M. Gaudin, H. M. Macdonald, A. B. Eidels, L. Rolf, J. M.
Description	Author Affiliation: Rolf JM ( Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.);
Abstract	An anti-idiotypic serum prepared against the combining site (idiotype) of specific anti-diphtheria toxoid antibodies was characterized with respect to its interaction with highly diphtheria toxin-sensitive Vero cells. Although the anti-idiotypic serum protected Vero cells against the cytotoxic action of diphtheria toxin, it did not prevent the binding of 125I-labeled diphtheria toxin to the cells but did inhibit the internalization and degradation of 125I-labeled toxin. This anti-idiotypic serum immunoprecipitated a cell-surface protein from radiolabeled Vero cells with an apparent Mr of approximately 15,000. These results are consistent with the hypothesis that the anti-idiotypic serum contains antibodies that carry an internal image of an internalization site on the toxin and that a cell-surface protein involved in toxin internalization possesses a complementary site recognized by both the toxin and the anti-idiotypic antibodies.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diphtheria Toxin Pharmacology Immune Sera Immunoglobulin Idiotypes Immunology Receptors, Cell Surface Animals Cell Survival Metabolism Electrophoresis, Polyacrylamide Gel Epitopes Heparin-binding EGF-like Growth Factor Immunosorbent Techniques Intercellular Signaling Peptides And Proteins Iodine Radioisotopes Molecular Weight Receptors, Cholinergic Vero Cells Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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