NDLI: In vitro culture of primary plasmacytomas requires stromal cell feeder layers.

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In vitro culture of primary plasmacytomas requires stromal cell feeder layers.

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In vitro culture of primary plasmacytomas requires stromal cell feeder layers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, A. O. Hilbert, D. M. Rudikoff, S. Coon, H. G. Degrassi, A. Potter, M.
Description	Author Affiliation: Degrassi A ( Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.);
Abstract	Attempts to grow primary murine plasmacytomas in vitro have, to date, been largely unsuccessful. In this study, we demonstrate that long-term in vitro growth of primary plasmacytomas is accomplished by using feeder layers composed of stromal cells from the initial site of plasmacytomagenesis. The early neoplastic lines established in this manner are dependent on physical contact with the stromal layer, which is mediated in part by CD44, for growth and survival. The stromal cells provide at least two stimuli for the plasma cells, one being interleukin 6 and the second, of unknown nature, resulting from direct physical interaction that cannot be replaced by soluble factors. These plasma cell lines have been passaged for as long as 20 months yet still maintain characteristics associated with primary plasmacytomas as they will grow in vivo only in pristane-primed animals, indicating a continued dependence on the pristane-induced microenvironment characteristic of early-stage tumors. The ability to grow primary plasmacytomas in culture and maintain their 'primary' properties provides a model system for detailed analysis of early events in plasma cell tumor progression involving neoplastic cells completely dependent on physical contact with a stromal feeder layer for survival and expansion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Plasma Cells Cytology Plasmacytoma Pathology Animals Antigens, Surface Cell Adhesion Cell Adhesion Molecules Physiology Gene Rearrangement, B-Lymphocyte, Heavy Chain Hyaluronoglucosaminidase Pharmacology Immunoglobulins Metabolism Immunophenotyping In Vitro Techniques Mice Mice, Inbred BALB C Microscopy, Electron Receptors, Lymphocyte Homing Receptors, Very Late Antigen Tumor Cells, Cultured Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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