NDLI: Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.

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Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.

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Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kohn, E. C. Ma, A. L. Felder, C. C. Macarthur, L. Gusovsky, F.
Description	Author Affiliation: Felder CC ( Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.);
Abstract	Several members of the family of guanine nucleotide-binding protein (G protein)-coupled receptors have recently been shown to induce agonist-dependent foci development in NIH 3T3 cells and tumors in nude mice. We selected the five subtypes of the muscarinic acetylcholine receptor family to investigate their role in tumor suppression. When transfected and expressed in CHO-K1 Chinese hamster ovary cells, m1, m3, and m5 muscarinic acetylcholine receptor activation resulted in a morphology change. Receptor activation did not slow or inhibit monolayer growth of CHOm5 cells in culture but markedly inhibited density-independent growth in soft agar and suppressed tumor formation in nude mice. Receptor-mediated tumor suppression was found to be agonist-dependent and reversible and was blocked with a muscarinic receptor antagonist. Of the five signaling pathways associated with the m1, m3, and m5 receptors, only receptor-operated, and inositol trisphosphate-independent, calcium influx was found to correlate with inhibition of tumorigenicity. These data suggest a pivotal role for inositol trisphosphate-independent receptor-regulated calcium homeostasis in CHO-K1 tumor suppression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Channels Physiology Calcium Receptors, Muscarinic Animals CHO Cells Carbachol Pharmacology Cricetinae In Vitro Techniques Ion Channel Gating Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental Pathology Physiopathology Phosphoproteins Metabolism Phosphotyrosine Second Messenger Systems Transfection Tumor Cells, Cultured Tyrosine Analogs & Derivatives Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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