NDLI: Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

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Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

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Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nagata, S. Adachi, M. Watanabe-fukunaga, R.
Description	Author Affiliation: Adachi M ( Osaka Bioscience Institute, Japan.);
Abstract	The mouse lpr (lymphoproliferation) mutation carries a rearrangement in the chromosomal gene for the Fas antigen, which mediates apoptosis. Isolation and characterization of mouse Fas antigen chromosomal gene from wild-type and lpr mice indicated an insertion of an early transposable element (ETn) in intron 2 of the Fas antigen gene of lpr mice. Hybrid transcripts carrying the Fas antigen and ETn sequences were expressed in the thymus and liver of the mutant. This indicated that premature termination and aberrant splicing of the Fas antigen transcript caused by the insertion of the ETn in the intron are responsible for the lymphoproliferation and autoimmune phenotype of the mutant mouse. On the other hand, an insertion of the ETn into an intron of a mammalian expression vector dramatically but not completely reduced the expression efficiency. These findings suggest that lpr mice are able to express a very low level of the Fas antigen.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Surface Genetics DNA Transposable Elements Gene Expression Regulation Lymphoproliferative Disorders Amino Acid Sequence Animals Antigens, CD95 Apoptosis Introns Mice Mice, Mutant Strains Molecular Sequence Data Oligodeoxyribonucleotides Chemistry Polymerase Chain Reaction RNA Splicing RNA, Messenger Restriction Mapping Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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