NDLI: Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

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Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

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Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cai, Z. Okada, Y. Ohwaki, M. Matsuoka, Y. Ishikawa, H. Umesaki, Y. Matsumoto, S. Nanno, M. Shimamura, T. Kawaguchi, M.
Description	Author Affiliation: Kawaguchi M ( Yakult Central Institute for Microbiological Research, Tokyo, Japan.);
Abstract	We have compared the cytolytic activities and the cellular compositions of the intestinal intraepithelial lymphocyte (i-IEL) populations in three different combinations of conventional (CV) and germ-free (GF) mice. Cytolytic activity of i-IELs expressing gamma delta T-cell antigen receptors (TCRs) is strain dependent in CV mice (high vs. low), and this strain-dependent variability is unaltered in the GF condition. Although absolute numbers of gamma delta i-IELs are slightly decreased, the composition of CD8 alpha alpha+ and CD4-CD8- subsets and the usage of TCR gamma- and delta-chain variable gene segments by gamma delta i-IELs remain the same in GF mice. By contrast, cytolytic activity of alpha beta TCR-expressing i-IELs is uniformly high in CV mice but attenuated sharply in the GF condition. A conspicuous decrease in the total numbers of alpha beta i-IELs is also noted, and CD8 alpha beta+ and CD4+CD8+ subsets are reduced, whereas the CD8 alpha alpha+ subset is expanded in GF mice. These results indicate that microbial deprivation preferentially influences the alpha beta i-IEL population to decrease and become noncytolytic but has little effect on the pool size or characteristics of gamma delta i-IELs. Consequently, cytolytic activity of freshly isolated i-IELs from GF mice is determined by T cells expressing gamma delta TCRs and is found to be strain dependent.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytotoxicity, Immunologic Intestines Immunology Receptors, Antigen, T-Cell, Gamma-delta Biosynthesis T-Lymphocyte Subsets T-Lymphocytes Animals Antibodies, Monoclonal Antigens, CD3 Cells, Cultured Epithelium Fluorescent Antibody Technique Cytology Kinetics Mast-Cell Sarcoma Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Phenotype Receptors, Antigen, T-Cell, Alpha-beta Genetics Tumor Cells, Cultured Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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