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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Streeter, P. R. Michie, S. Butcher, E. C. Mebius, R. E. Weissman, I. L. |
| Description | Author Affiliation: Mebius RE ( Department of Pathology, Stanford University School of Medicine, CA 94305, USA.); |
| Abstract | IN adult mice, the dominant adhesion molecules involved in homing to lymph nodes are L-selectin homing receptors on lymphocytes and the peripheral lymph node addressins on specialized high endothelial venules. Here we show that, from fetal life through the first 24 hr of life, the dominant adhesion molecules are the mucosal addressin MAdCAM-1 on lymph node high endothelial venules and its counterreceptor, the Peyer's patch homing receptor, integrin alpha 4 beta 7 on circulating cells. Before birth, 40-70% of peripheral blood leukocytes are L-selectin-positive, while only 1-2% expresses alpha 4 beta 7. However, the fetal lymph nodes preferentially attract alpha 4 beta 7-expressing cells, and this can be blocked by fetal administration of anti-MAdCAM-1 antibodies. During fetal and early neonatal life, when only MAdCAM-1 is expressed on high endothelial venules, an unusual subset of CD4 + CD3- cells, exclusively expressing alpha 4 beta 7 as homing receptors, enters the lymph nodes. Beginning 24 hr after birth a developmental switch occurs, and the peripheral node addressins are upregulated on high endothelial venules in peripheral and mesenteric lymph nodes. This switch in addressin expression facilitates tissue-selective lymphocyte migration and mediates a sequential entry of different cell populations into the lymph nodes. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Surface Metabolism CD4-Positive T-Lymphocytes Cytology Endothelium, Vascular Immunoglobulins Integrin Beta Chains Lymph Nodes Embryology Mucoproteins Receptors, Lymphocyte Homing Animals Animals, Newborn Immunology Antigens, CD Cell Adhesion Molecules Cell Movement Integrin Alpha4 Integrins L-Selectin Lymphocyte Subsets Lymphoid Tissue Membrane Proteins Mice Mice, Inbred C57BL Tissue Distribution Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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