NDLI: Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.

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Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.

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Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zoldhelyi, P. Chesebro, J. H. Owen, W. G.
Description	Author Affiliation: Zoldhelyi P ( Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905.);
Abstract	The amount of thrombin active in vivo in the intravascular space (blood and endothelial surface), both basally and in experimental intravascular coagulation, is measured by way of the accessibility of thrombin to intravascular hirudin. Blood samples from pigs given intravenous 125I-labeled hirudin contain 125I-labeled hirudin-thrombin complex in concentrations indicative of a basal thrombin concentration in vivo of 0.5 nmol/liter. Intravenous infusion of Salmonella endotoxin elicits an increase in the circulating concentration of hirudin-thrombin complex that begins within 15 min and is 20-30 times basal after 4 hr. Induction of mild intravascular coagulation is evidenced by a modest reduction in plasma fibrinogen concentrations. It is concluded that there is a basal pool of hirudin-accessible thrombin in the intravascular space that, were it free in the plasma phase, would be sufficient in principle to sustain intravascular coagulation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Coagulation Hirudins Thrombin Metabolism Animals Calcium Disseminated Intravascular Coagulation Endothelium, Vascular Extracellular Space Pharmacokinetics Metabolic Clearance Rate Protein Binding Rats, Sprague-Dawley Recombinant Proteins Species Specificity Swine Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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