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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bao, Clare Cao, Wangsen Lowenstein, Charles J. |
| Description | Author Affiliation: Cao W ( Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. wcao1@jhmi.edu); |
| Abstract | Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (NOS2). The amino-terminal portion of E1A decreases transactivation of the NOS2 5'-flanking region, limiting the DNA binding activity of NF-kappaB and inhibiting NOS2 expression. E1A is thus able to deactivate a critical component of the host defense against viral infection. Viral inhibition of NO production is a mechanism that may enable certain viruses to evade the host innate immune system. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 100 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2003-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adenovirus E1A Proteins Genetics Nitric Oxide Synthase Biosynthesis Acetyltransferases Metabolism Adenoviridae Animals Blotting, Northern Cell Line Cell Nucleus DNA Gene Expression Regulation Genetic Vectors HeLa Cells Histone Acetyltransferases Immunohistochemistry Interferons Macrophages Mice NF-kappa B Nitric Oxide Nitric Oxide Synthase Type II Peroxynitrous Acid Pharmacology Plasmids Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Saccharomyces Cerevisiae Proteins Time Factors Transcription, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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