NDLI: Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.

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Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.

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Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Englund, Ulrica Bjorklund, Anders Kokaia, Merab Wictorin, Klas Lindvall, Olle
Description	Author Affiliation: Englund U ( Sections of Neurobiology and Restorative Neurology, Wallenberg Neuroscience Center, BMC A-11, Lund University, S-221 84 Lund, Sweden Europe.);
Abstract	In vitro expanded neural stemprogenitor cells can undergo region-specific differentiation after transplantation to the developing or adult brain, and display morphologies and markers characteristic of mature neurons. Here we have used patch-clamp techniques to explore whether grafted stem cells also can develop physiological properties of mature neurons and become functionally integrated within host neural circuitry. The immortalized neural progenitor cell line, RN33B, prelabeled with GFP by using a lentiviral vector, was transplanted into the cortex or hippocampus of neonatal rats. We found that the grafted GFP-positive cells differentiated into cells with morphological features of cortical or hippocampal pyramidal neurons, and that many of them had established appropriate cortico-thalamic and contralateral hippocampal connections, respectively, as revealed by retrograde tracing. Whole-cell patch-clamp recordings from grafted cells with morphological characteristics of pyramidal neurons showed that they were able to generate action potentials, and received functional excitatory and inhibitory synaptic inputs from neighboring cells. These data provide evidence that grafted neural progenitors can differentiate into morphologically mature pyramidal projection neurons, establish appropriate long-distance axonal projections, exhibit normal electrophysiological properties, and become functionally integrated into host cortical circuitry.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Cortex Physiology Neurons Transplantation Pyramidal Cells Stem Cell Transplantation Stem Cells Action Potentials Animals Axons Cell Differentiation Cell Line Hippocampus Receptors, N-Methyl-D-Aspartate Synapses Gamma-Aminobutyric Acid Secretion Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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