NDLI: Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2002 Volume: 99 Issue: 26

Mutational analysis of the structural organization of polyglutamine aggregates.

Neural correlates of perceptual learning: a functional MRI study of visual texture discrimination.

A highly $Ca^{2+}-sensitive$ pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells

NOSTRIN: A protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

Directed evolution of a genetic circuit.

Longitudinal pattern of basilar membrane vibration in the sensitive cochlea.

Site-directed recombination via bifunctional PNA-DNA conjugates.

Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

Bacillus thuringiensis-toxin resistance management: stable isotope assessment of alternate host use by Helicoverpazea.

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.

Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

Evidence for vestibular regulation of autonomic functions in a mouse genetic model.

Stomatocyte-discocyte-echinocyte sequence of the human red blood cell: evidence for the bilayer- couple hypothesis from membrane mechanics.

Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis.

Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation.

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.

Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry.

An Ethiopian pattern of human adaptation to high-altitude hypoxia.

Lévy laws in free probability.

Lévy processes in free probability.

Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States.

Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence.

Associations between human disease genes and overlapping gene groups and multiple amino acid runs.

Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast.

Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.

Noninvasive real-time imaging of apoptosis.

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication.

Protection against ischemic brain injury by protein therapeutics.

Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts.

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter.

Association testing by DNA pooling: an effective initial screen.

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.

G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.

Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex.

Genetic variation in the 22q11 locus and susceptibility to schizophrenia.

The role of feedback in shaping neural representations in cat visual cortex.

Soft and hard classification by reproducing kernel Hilbert space methods.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Spin-dependent mechanism for diatomic ligand binding to heme

Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.

Circadian clock protein KaiC forms ATP-dependent hexameric rings and binds DNA.

Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.

An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa.

Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery.

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.

Trbp111 selectively binds a noncovalently assembled tRNA-like structure.

Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase.PhCH2O- complex.

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.

An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a.

Genomic diversity of enterohemorrhagic Escherichia coli O157 revealed by whole genome PCR scanning.

CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.

Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.

The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.

Dynamics and selection of many-strain pathogens.

Allopolyploidization and evolution of species with reduced floral structures in Lepidium L. (Brassicaceae)

Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line.

Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex.

Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice.

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

More antibody with less antigen: can immunogenicity of attenuated live virus vaccines be improved?

Chemical complementation: a reaction-independent genetic assay for enzyme catalysis.

Direct imaging of nanoscale magnetic interactions in minerals.

Modularity and reshuffling of Snail and Slug expression during vertebrate evolution.

Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: Decreased stability of the apo state

Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP

High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools.

The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta.

A molecular switch underlies a human telomerase disease.

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE.

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice.

A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist.

Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons.

Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats

Distribution of nitric oxide synthase in normal and cirrhotic human liver.

Premonitory patterns of seismicity months before a large earthquake: five case histories in Southern California.

Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.

Interaction of pollinators and herbivores on plant fitness suggests a pathway for correlated evolution of mutualism- and antagonism-related traits.

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach.

A-317491, a novel potent and selective non-nucleotide antagonist of $P2X_{3}$ and $P2X_{2/3}$ receptors, reduces chronic inflammatory and neuropathic pain in the rat

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics.

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.

A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae.

Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins.

Dynamics of microtubule asters in microfabricated chambers: the role of catastrophes.

Genome-wide coexpression dynamics: Theory and application

Engineered calmodulins reveal the unexpected eminence of $Ca^{2+}$ channel inactivation in controlling heart excitation

Crop pollination from native bees at risk from agricultural intensification.

Photoresponsive polymer-enzyme switches.

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion.

ARF mutation accelerates pituitary tumor development in Rb+/- mice.

Anaerobic enzyme⋅substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase

Differential lipid biosynthesis underlies a tradeoff between reproduction and flight capability in a wing-polymorphic cricket.

Carotenoid to chlorophyll energy transfer in the peridinin-chlorophyll-a-protein complex involves an intramolecular charge transfer state.

Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.

Reversal of DNA alkylation damage by two human dioxygenases.

A polyphosphate kinase (PPK2) widely conserved in bacteria

Z-DNA-binding proteins can act as potent effectors of gene expression in vivo.

There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling.

Can the $Ca^{2+}$ hypothesis and the $Ca^{2+}-voltage$ hypothesis for neurotransmitter release be reconciled?

Hyperinsulinism induced by targeted suppression of beta cell $K_{ATP}$ channels

Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter.

Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA.

Properties of linkage disequilibrium (LD) maps.

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity.

Topology of the $Ca^{2+}$ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)

Gene function: getting specific, generally speaking.

Design then mutate.

Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways.

Revealingly odd couples.

Increased level of hemoglobin 1 enhances survival of hypoxic stress and promotes early growth in Arabidopsis thaliana.

Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo.

Autoantibodies against alpha -MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients.

Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells

Sensitization of regulated exocytosis by protein kinase C

Linking brain and behavior in sleep-dependent learning and memory consolidation.

Year: 2002 Volume: 99 Issue: 25

Year: 2002 Volume: 99 Issue: 24

Year: 2002 Volume: 99 Issue: 23

Year: 2002 Volume: 99 Issue: 22

Year: 2002 Volume: 99 Issue: 21

Year: 2002 Volume: 99 Issue: 20

Year: 2002 Volume: 99 Issue: 19

Year: 2002 Volume: 99 Issue: 18

Year: 2002 Volume: 99 Issue: 17

Year: 2002 Volume: 99 Issue: 16

Year: 2002 Volume: 99 Issue: 15

Year: 2002 Volume: 99 Issue: 14

Year: 2002 Volume: 99 Issue: 13

Year: 2002 Volume: 99 Issue: 12

Year: 2002 Volume: 99 Issue: 11

Year: 2002 Volume: 99 Issue: 10

Year: 2002 Volume: 99 Issue: 9

Year: 2002 Volume: 99 Issue: 8

Year: 2002 Volume: 99 Issue: 7

Year: 2002 Volume: 99 Issue: 6

Year: 2002 Volume: 99 Issue: 5

Year: 2002 Volume: 99 Issue: 4

Year: 2002 Volume: 99 Issue: Suppl 4

Year: 2002 Volume: 99 Issue: 3

Year: 2002 Volume: 99 Issue: Suppl 3

Year: 2002 Volume: 99 Issue: 2

Year: 2002 Volume: 99 Issue: Suppl 2

Year: 2002 Volume: 99 Issue: 1

Year: 2002 Volume: 99 Issue: Suppl 1

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huguenard, John R. Bacci, Alberto Prince, David A.
Description	Author Affiliation: Bacci A ( Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 USA.);
Abstract	Neuropeptide Y (NPY) is widely expressed throughout the nervous system and is known to reduce excitatory (but also inhibitory) synaptic transmission in many CNS areas, leading to the proposal that it is an endogenous antiepileptic agent. In the neocortex, where NPY is present in gamma-aminobutyric acid (GABA)ergic interneurons, its effects on inhibitory and excitatory synaptic activities have not been completely explored. Here we report that NPY application elicits a long-lasting decrease in evoked excitatory postsynaptic current amplitude and a delayed, long-lasting increase in the amplitude of evoked monosynaptic inhibitory postsynaptic current (IPSC) in layer V pyramidal neurons of rat neocortex. The novel, late, NPY-mediated increase of inhibitory synaptic transmission is caused by modulation of Ca2+-dependent GABA release onto pyramidal neurons, as it was accompanied by an increase in Ca2+-dependent miniature IPSC frequency. NPY decreased evoked monosynaptic IPSCs in GABAergic interneurons, indicating that this neuropeptide has differential effects on different neuronal subtypes in the neocortex. Each of these NPY actions would decrease excitability in cortical circuits, a result that has important implications for both physiological neocortical operations as well as pathophysiological epileptiform activities.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neocortex Drug Effects Neuropeptide Y Pharmacology Synaptic Transmission Animals Interneurons Physiology Membrane Potentials Pyramidal Cells Rats, Sprague-Dawley Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in