NDLI: Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.

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Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.

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Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Latour, Jean-marc D'autreaux, Benoit Bersch, Beate Michaud-soret, Isabelle Touati, Daniele
Description	Author Affiliation: D'Autreaux B ( Laboratoire de Physicochimie des Métaux en Biologie (Formation de Recherche en Evolution-Université Joseph Fourier-Commissariat à l'Energie Atomique-Centre National de la Recherche Scientifique no. 2427), Grenoble, F-38054 Grenoble Cedex 9, France.);
Abstract	Ferric uptake regulation protein (Fur) is a bacterial global regulator that uses iron as a cofactor to bind to specific DNA sequences. The function of Fur is not limited to iron homeostasis. A wide variety of genes involved in various mechanisms such as oxidative and acid stresses are under Fur control. Flavohemoglobin (Hmp) is an NO-detoxifying enzyme induced by NO and nitrosothiol compounds. Fur recently was found to regulate hmp in Salmonella typhimurium, and in Escherichia coli, the iron-chelating agent 2,2'-dipyridyl induces hmp expression. We now establish direct inhibition of E. coli Fur activity by NO. By using chromosomal Fur-regulated lacZ reporter fusion in E. coli, Fur activity is switched off by NO at micromolar concentration. In vitro Fur DNA-binding activity, as measured by protection of restriction site in aerobactin promoter, is directly sensitive to NO. NO reacts with Fe(II) in purified FeFur protein to form a S = 12 low-spin FeFur-NO complex with a g = 2.03 EPR signal. Appearance of the same EPR signal in NO-treated cells links nitrosylation of the iron with Fur inhibition. The nitrosylated Fur protein is still a dimer and is stable in anaerobiosis but slowly decays in air. This inhibition probably arises from a conformational switch, leading to an inactive dimeric protein. These data establish a link between control of iron metabolism and the response to NO effects.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Antagonists & Inhibitors Metabolism Nitric Oxide Physiology Repressor Proteins Transcription, Genetic Chemistry Dimerization Electron Spin Resonance Spectroscopy Escherichia Coli Protein Conformation Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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