NDLI: A highly $Ca^{2+}-sensitive$ pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells

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A highly $Ca^{2+}-sensitive$ pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells

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A highly $Ca^{2+}-sensitive$ pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Yan Udayasankar, Sangeetha Dunning, James Gillis, Kevin D. Chen, Peng
Description	Author Affiliation: Yang Y ( Departments of Biological Engineering, Electrical Engineering, and Physiology, and Dalton Cardiovascular Research Center, University of Missouri, Research Park Drive, Columbia, MO 65211, USA.);
Abstract	We have used flash photolysis of caged Ca2+ and membrane capacitance measurements to probe exocytosis in chromaffin cells at low concentrations of intracellular Ca2+ ([Ca2+]i) (<10 microM). We observed a small pool of granules that is more sensitive to [Ca2+]i than the previously described 'readily releasable pool.' Upon activation of PKC, this 'highly Ca2+-sensitive pool' is enhanced in size to a greater extent than the readily releasable pool but is eliminated upon expression of a C-terminal deletion mutant (Delta9) of synaptosome-associated protein of 25 kDa (SNAP-25). Thus, in chromaffin cells, PKC enhances exocytosis both by increasing the number of readily releasable vesicles and by shifting vesicles to a highly Ca2+-sensitive state, enabling exocytosis at sites relatively distant from Ca2+ channels.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Metabolism Chromaffin Cells Exocytosis Protein Kinase C Physiology Secretory Vesicles Animals Calcium Channels Cells, Cultured Enzyme Activation Membrane Proteins Nerve Tissue Proteins Synaptosomal-Associated Protein 25 Tetradecanoylphorbol Acetate Pharmacology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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