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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhan, Min Wen, Feiqiu Liu, Lijuan Chen, Zebin Wei, Hong Zhou, Honghao |
| Description | Author Affiliation: Zhan M ( Shen Zhen Children's Hospital, Shenzhen, 510038, People's Republic of China.); Wen F ( Shen Zhen Children's Hospital, Shenzhen, 510038, People's Republic of China.); Liu L ( Jiangxi Provincial Cancer Hospital, Nanchang, 330029, People's Republic of China.); Chen Z ( Shen Zhen Children's Hospital, Shenzhen, 510038, People's Republic of China.); Wei H ( Shen Zhen Children's Hospital, Shenzhen, 510038, People's Republic of China.); Zhou H ( Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People's Republic of China. hhzhou2003@163.com.) |
| Abstract | Lung cancer is the most common cause of cancer-related deaths worldwide, and non-small cell lung cancer (NSCLC) accounts for 80 to 85 % of all lung cancer. Although the standard treatment regimen has been established, long-term survival for NSCLC patients is still generally poor. The histone demethylase Jumonji domain containing 1A (JMJD1A) has been proposed as an oncogene in several types of human cancer, but its clinical significance and functional roles in NSCLC remain largely unclear. In the present study, JMJD1A was frequently upregulated in NSCLC compared with para-carcinoma tissues. JMJD1A knockdown significantly inhibited NSCLC cell growth, migration, and invasion in vitro and tumorigenesis in vivo. Further experiments demonstrated that JMJD1A knockdown could decrease the expression of EZH2, which has been shown to play a crucial role in the carcinogenesis of NSCLC and, in turn, increase the expression of anti-tumor microRNA let-7c. Also, let-7c directly targeted the 3'-untranslated regions of JMJD1A and EZH2. Taken together, JMJD1A could promote NSCLC tumorigenesis. JMJD1A/EZH2/let-7c constituted a feedback loop and might represent a promising therapeutic target for NSCLC. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 8 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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