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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoshida, Takashi Kinoshita, Hidefumi Yoshida, Kenji Mishima, Takao Yanishi, Masaaki Inui, Hidekazu Komai, Yoshihiro Sugi, Motohiko Inoue, Takaaki Murota, Takashi Fukui, Katsuya Harada, Jiro Kawa, Gen Matsuda, Tadashi |
| Description | Country affiliation: Japan Author Affiliation: Yoshida T ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Kinoshita H ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan. kinoshih@hirakata.kmu.ac.jp.); Yoshida K ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Mishima T ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Yanishi M ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Inui H ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Komai Y ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Sugi M ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.); Inoue T ( Department of Urology and Andrology, Takii Hospital, Kansai Medical University, Hirakata, Osaka, Japan.); Murota T ( Department of Urology and Andrology, Takii Hospital, Kansai Medical University, Hirakata, Osaka, Japan.); Fukui K ( Department of Urology and Andrology, Kori Hospital, Kansai Medical University, Hirakata, Osaka, Japan.); Harada J ( Department of Urology, Saiseikai Noe Hospital, Osaka, Japan.); Kawa G ( Department of Urology, Saiseikai Noe Hospital, Osaka, Japan.); Matsuda T ( Department of Urology and Andrology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.) |
| Abstract | Various systemic inflammatory response biomarkers are associated with oncological outcome. We evaluated the superiority of prognostic predictive accuracy between neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR), and the prognostic significance of their perioperative change in patients with bladder cancer undergoing radical cystectomy (RC). We retrospectively analyzed 302 patients who had undergone RC in four institutions. Comparison of predictive accuracy between NLR and LMR was performed using receiver operating characteristic curve analysis. Overall survival (OS) and cancer-specific survival (CSS) were assessed with the Kaplan-Meier method and Cox regression analysis. Preoperative and postoperative LMR showed higher predictive accuracy for OS than NLR did (p = 0.034). Applying a cutoff of 3.41, change in perioperative LMR stratified patients into three groups (low, intermediate, and high risk), showing a significant difference in OS and CSS (p < 0.001, each), and pathological outcomes. Multivariable analyses for OS and CSS showed that poor changes in LMR (high risk) were an independent prognostic factor (hazard ratio 5.70, 95 % confidence interval 3.49-9.32, p < 0.001; hazard ratio 4.53, 95 % confidence interval 2.63-7.82, p < 0.001; respectively). Perioperative LMR is significantly associated with survival in patients with bladder cancer after RC, and it is possibly superior to NLR as a prognostic factor. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 8 |
| Journal | Tumor Biology |
| Volume Number | 37 |
| e-ISSN | 14230380 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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